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Description
Renue By Science Trigonelline | High Strength Trigonelline TRG Methylated Niacin - 250mg Trigonilline Supplement Capsules | Non-GMO | Made in The USA & Third-Party TestedRenue By Science Trigonelline TRG Methylated Niacin 250mg supplement capsules. Non GMO. Made in the USA. Third Party Tested. Muscle NAD+ Synthesis: By promoting NAD+ synthesis in muscle through the Preiss Handler pathway, Trigonelline enhances cellular energy and repair, supporting overall health and longevity. Supports muscle NAD+ production, unlike NMN or NR. It provides the precursors needed to generate NAD+ that becomes depleted through cellular
Renue By Science Trigonelline TRG Methylated Niacin 250mg supplement capsules. Non-GMO. Made in the USA. Third-Party Tested.
- Muscle NAD+ Synthesis: By promoting NAD+ synthesis in muscle through the Preiss-Handler pathway, Trigonelline enhances cellular energy and repair, supporting overall health and longevity. Supports muscle NAD+ production, unlike NMN or NR. It provides the precursors needed to generate NAD+ that becomes depleted through cellular metabolism and aging.
- DNA Repair and Cellular Integrity: Encouraging cellular repair and maintaining DNA integrity, Trigonelline protects against cellular damage and promotes health at the molecular level. Additionally donates methyl groups which promote healthy gene expression.
- Protects Against Tissue Aging: Supplies much-needed NAD+ precursors to tissues like the heart, brain, and muscles. NAD+ declines fastest in tissues that experience the most oxidative damage and physiological use, so using Trigonelline to refuel these tissues protects youthful heart, brain, and muscle function, preserving strength and cognition.
- Broad Longevity Support: Unlike other NAD+ precursors, Trigonelline is stable through digestion and enters circulation for systemic tissue delivery. Once in circulation it can support healthy sugar and lipid metabolism and does not cause the flushing effect that many experience with niacin.
- Naturally Occurring NAD+ Support: Trigonelline is found in numerous plant foods including coffee and fenugreek. This highly bioavailable and stable molecule can cross the blood-brain barrier and is quickly metabolized into NAD+, measurably impacting circulating and intracellular levels of this critical molecule.
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Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
- Final sale items are not eligible for returns or exchanges.
- To process your return/exchange, please contact us at [email protected]
- Please click here for more details>>> Return & Exchange Policy
4.5 ★★★★★
Based on 19 reviews
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Product Reviews
★★★★★ 3
Pretty Good But Not Perfect!
Size: 28'' X 34''
I have been using two of these frames for my miniature poodle puppy for almost a month now and while they are useful, they could be improved. The size of the frames are great for our miniature size poodle puppy and the Amazon pads that fit the frames absorb well without leaking underneath. The grips on the bottom of the frame keep it in place so it does not slide across floor. The frame hinges in the center so you can easily carry it through doorways. I am in my 60's so it is nice to be able to carry it to my work table in order to change pads while standing up.
My 4 month old 10 pound puppy can make a dinner plate size circle of pee onto the pad first thing in the morning. 4 large pees are easily held by the pee pads before needing to change it but we prefer to change the pads more often for sanitary reasons. Not sure if you have a very large breed dog that these would work for you. Our puppy likes going on these without hesitation so they are comfortable for him to walk around on and turn to find just the right spot!
Compared to other brands I have looked at this is a great value for money and worth a try to help with potty training your pup. Our puppy sleeps in an X-pen inside of our home at night and when we are gone so these help with keeping the pads where we want them. We have two - one inside X-pen and one by door where we are training puppy to go outside.
These frames are nice in appearance and seem like they will last but they are a little awkward to use compared to another brand I purchased which was more durable and easier to change pad. I ended up with these because other brands do not offer such a large size (28 x 34).
Our main complaints about these frames are:
1. The top frame is hinged and a little wobbly to manuever over the edges of the pee pads. Another brand, while a bit smaller, has a solid one piece frame that goes over entire pad in one step. This frame requires a three step process of laying pad down, pulling edges out flat and placing one side of frame down and then repeating on other side. There is usually a bit of adjustment that needs to be done and so requires opening and closing the frame again for adjustments.
2. The Amazon pee pads that fit this frame hold the pee well without leaking but have very thin tissue paper like edges (blue) that do not extend out far enough to make capturing the edges of the pee pad under the frame very easy to maneuver. It would be a game changer if the pads were made at least 1" bigger around length and width so edges are firmly held in place.
3. Our tiny 10 pound poodle pup is able to easily dig out edges of pad and tear it up. Not as bad as a loose pad by any means, but blue edges are exposed at side centers where frame hinges and there is no cover of edges (unlike a one piece frame) and the blue color seems to attract him. He can dig and loosen pad on any side because there is no way to hide and hold down all of the blue edges of pee pad.
I am still using these to potty train and, as I said earlier, these are way better than loose pee pads. I may shop for even larger size pee pads in the future to better lock down all of the edges without so much difficulty.
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Reviewed in the United States on May 5, 2026
★★★★★ 4
Good product for dog training.
Size: 22'' X 22''
Work for the most part. Dogs will chew on it so wipe it down with dawn dish soap. Hard to clean where it clips down.
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Reviewed in the United States on March 13, 2026
★★★★★ 5
Saving My Floors
Size: 28'' X 34'', Size: 28'' X 34''
Omg, what a game changer. My pups like to destroy the pads whenever they get the chance to. With this they still try but never succeed. I will say that it can be a little sturdier as the handles are a little flimsy, but I manage and it does the job. It's very easy to use when I change the pads and I use 2 pads for coverage. I just placed it where I usually place their pads and it fits right in the spot. They are trained to go outside but on rainy days this comes in handy. To save my floors it's definitely worth the money spent.
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Reviewed in the United States on April 26, 2026
★★★★★ 5
Yes!
Size: Medium
Durable. Squeak doesn't last forever with my aggressive chewers but crinkle does. Best balls.
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Reviewed in the United States on September 28, 2025
★★★★★ 5
Balls
Size: Medium
My dog loves chasing these balls. He seems to love the squeak! They fit the chuck it stick perfectly, and are great replacements for the originals that came with the stick.
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Reviewed in the United States on February 7, 2026
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