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Description
CDC7 Recombinant Rabbit mAb (S-2159-50)Product Specification Host Rabbit Antigen CDC7 Synonyms Cell division cycle 7 related protein kinase; CDC7 related kinase; HsCdc7; huCdc7; CDC7L1 Immunogen Recombinant Protein Location Nucleus Accession O00311 Clone Number S 2159 50 Antibody Type Recombinant mAb Isotype IgG Application WB, ICC Reactivity Hu Positive Sample HeLa, Jurkat, PC 3, T 47D, MDA MB 231 Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance
Product Specification
| Host | Rabbit |
| Antigen | CDC7 |
| Synonyms | Cell division cycle 7-related protein kinase; CDC7-related kinase; HsCdc7; huCdc7; CDC7L1 |
| Immunogen | Recombinant Protein |
| Location | Nucleus |
| Accession | O00311 |
| Clone Number | S-2159-50 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, ICC |
| Reactivity | Hu |
| Positive Sample | HeLa, Jurkat, PC-3, T-47D, MDA-MB-231 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
| ICC | 1:500 | Hu |
Background
CDC7 (cell division cycle 7-related protein kinase) is a highly conserved, nuclear serine/threonine kinase encoded by the CDC7 gene that governs the initiation of DNA replication at the G1/S transition by forming an active complex with its regulatory subunit Dbf4 (ASK in mammals); this CDC7-Dbf4/ASK complex phosphorylates the MCM2–7 helicase components of the pre-replication complex, thereby triggering origin firing and S-phase entry, while its activity is kept constant throughout the cell cycle by post-translational control rather than changes in CDC7 levels. Loss or inhibition of CDC7 arrests DNA synthesis and can lead to p53-mediated apoptosis, whereas its overexpression—frequently observed in colorectal, lung, breast and hematological malignancies—correlates with neoplastic transformation and may be exploited therapeutically with CDC7 inhibitors.
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