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Description
Alexa Fluor® 488 Rat Anti-Mouse CD172a (SIRPα) Antibody (S-R713)Product Specification Host Rat Antigen CD172a Synonyms Tyrosine protein phosphatase non receptor type substrate 1; SHP substrate 1; SHPS 1; Brain Ig like molecule with tyrosine based activation motifs (Bit); CD172 antigen like family member A; Inhibitory receptor SHPS 1; MyD 1 antigen; Signal regulatory protein alpha 1 (Sirp alpha 1; mSIRP alpha1); p84; Bit; Myd1; Ptpns1; Shps1; Sirp; Sirpa Location Membrane Accession P97797 Clone Number S R713
Product Specification
| Host | Rat |
| Antigen | CD172a |
| Synonyms | Tyrosine-protein phosphatase non-receptor type substrate 1; SHP substrate 1; SHPS-1; Brain Ig-like molecule with tyrosine-based activation motifs (Bit); CD172 antigen-like family member A; Inhibitory receptor SHPS-1; MyD-1 antigen; Signal-regulatory protein alpha-1 (Sirp-alpha-1; mSIRP-alpha1); p84; Bit; Myd1; Ptpns1; Shps1; Sirp; Sirpa |
| Location | Membrane |
| Accession | P97797 |
| Clone Number | S-R713 |
| Antibody Type | Rat mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | C57BL/6 mouse bone marrow |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | Alexa Fluor® 488 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Ms |
Background
CD172a, also known as SIRP alpha (signal-regulatory protein alpha), is a type I transmembrane glycoprotein belonging to the immunoglobulin superfamily. It is expressed on cells of myeloid origin, including monocytes, macrophages, dendritic cells, and granulocytes, but not on T and B lymphocytes. SIRP alpha plays a crucial role in immune regulation by interacting with its ligand, CD47, which is widely expressed on various cell types, including cancer cells. This interaction transmits a "do not eat me" signal to prevent phagocytosis of healthy cells and is involved in processes like dendritic cell-mediated T cell activation and neutrophil migration. Additionally, SIRP alpha has regulatory effects on cellular responses induced by growth factors, insulin, and oncogenes, and it is implicated in both physiological and pathological processes, such as cancer progression.
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Exchange/Return Notes
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