SKU: 75468693964

Mouse Anti-Human IgE Antibody (S-2853)

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Description

Mouse Anti-Human IgE Antibody (S-2853)Product Specification Host Mouse Antigen IgE Synonyms Immunoglobulin heavy constant epsilon; Ig epsilon chain C region; Ig epsilon chain C region ND; IGHE Location Secreted, Cell membrane Accession P01854 Clone Number S 2853 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Hu Positive Sample human PBMC Purification Protein G Concentration 2 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS pH7. 4 Stability &

Product Specification


Host Mouse
Antigen IgE
Synonyms Immunoglobulin heavy constant epsilon; Ig epsilon chain C region; Ig epsilon chain C region ND; IGHE
Location Secreted, Cell membrane
Accession P01854
Clone Number S-2853
Antibody Type Mouse mAb
Isotype IgG1,k
Application FCM
Reactivity Hu
Positive Sample human PBMC
Purification Protein G
Concentration 2 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS pH7.4
Stability & Storage

12 months from date of receipt / reconstitution, 2 to 8 °C as supplied

Dilution


application dilution species
FCM 1:2000 Hu

Background

IgE is an antibody isotype that, despite being the least abundant in serum, sits at the epicenter of type I hypersensitivity and anti-parasite immunity; generated by plasma cells in mucosal tissues, it binds with picomolar affinity to the tetrameric FcεRI on mast cells and basophils, priming them for rapid degranulation upon subsequent allergen encounter, thereby unleashing histamine, leukotrienes and cytokines that produce the clinical spectrum from urticaria to anaphylaxis, while also orchestrating eosinophil and macrophage responses against helminths; its half-life in plasma is brief (~2 days), yet it can remain cell-bound for weeks, and its levels are tightly regulated by IL-4, IL-13 and CD40L-mediated class-switching.

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Exchange/Return Notes
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SKU: 75468693964

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4.1 ★★★★★
Based on 11 reviews
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Verified Purchase
T-gal
Charlottesville, US
★★★★★ 5
So far, so good!
Finally! A toy my 55 pound, 18 month old puppy hasn’t destroyed in minutes, and one she actually LOVES playing with. It has a really cool bounce and she loves chasing it and it’s easy for her to grab and run back to me with. So glad it wasn’t another waste of money. My only suggestions are to make this in a fun color other than black, and to make other just as strong toys besides a donut (she already has 2 other donuts from different companies which surprisingly have weathered her jaws) and add a squeaker to one of these ultra strong toys. More than chasing the ball, she loves squeaking!
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Reviewed in the United States on May 8, 2026
M
Verified Purchase
Melissa j
Massapequa, US
★★★★★ 5
10/10 Great game changer for aggressive chewers
After a scary experience where our Doberman ingested part of a toy and needed emergency surgery, we had to get rid of all plush toys and small balls in our house. Replacing everything felt overwhelming. This ball has been fantastic. It’s truly built for aggressive chewers and holds up incredibly well. It’s perfect for fetch, strong enough for tug-of-war, and the bounce is excellent, which keeps our dog fully engaged during self-play when he’s entertaining himself. That unpredictable bounce makes it exciting without being unsafe. Most importantly, it gives us peace of mind. No shredding, no chunks coming off, no felt cover and constant worry about ingestion. Since having to replace all of his previous toys and balls, this one has stood out as the best by far. If you have a large, powerful dog—especially a Doberman—or a dog who destroys toys quickly, this is a must-have. Durable, safe, and genuinely fun. 10/10, highly recommend.
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Reviewed in the United States on January 21, 2026
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Verified Purchase
Crystal Knapp
Omaha, US
★★★★★ 5
Finally, a sturdy oversized ball my boy can't destroy! And can pick up easily
This is just wonderful! My dog has destroyed all other balls! I think this is finally one he cannot destroy. And I love the holes so he can pick it up and throw it himself. LOL. And it BOUNCES, bringing him endless joy and skill in catching it. Cause you don't know which way it will bounce off the ground. Oversize was just right for him. Glad to have found this great sturdy ball.
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Reviewed in the United States on April 29, 2026
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Verified Purchase
Kristi V.
Whiting, US
★★★★★ 4
Almost perfect...upraised logo should be left off
This toy is great for relentless chewers with strong jaws! It would be almost perfect if it didn't have a "K9" logo in raised rubber on it. That is the place that my aggressive chewer shepherd/bulldog mix focuses on and is able to get small chunks off. Without that logo, he would chew the ball more evenly, instead of fixating on that one spot. He loves this ball and has chewed on it for about an hour off & on each of the 11 days he has had it. Although it is very durable so far, the flaw is the upraised logo.
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Reviewed in the United States on January 22, 2026
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Verified Purchase
Ryan
New York, US
★★★★★ 5
Perfect for High-Drive Dogs & Surprisingly Durable (six month review)
I use this ring ball for structured fetch and tug sessions with my high-drive German Shepherd mix (91 lbs. at 10 mon.), and it’s easily the best toy we’ve added to our routine. What makes it truly exceptional is how it allows my dog to engage in the full canine predatory sequence: • Chase: He locks in visually and bolts after the ring when I throw it. • Grab & Hold: He brings it back, pins it against my leg, and bites down firmly (the toy—not the leg!)—his way of acting out the natural catch-and-control behavior. • Unalive & Tug: We finish with a strong tug session, which satisfies his instinct to grip and shake—basically his version of “making the toy unalive.” • Settle & Chew: Afterward, he relaxes with a chew toy or eats—completing the full physical and mental cycle in a healthy, balanced way. Durability is outstanding—this toy stands up to intense tug sessions with no tearing or damage, even with a 91 lb powerhouse. My senior dog also joins in for double tug play, and it holds up beautifully to that too. I don’t leave this toy down for chewing—it’s not a chew toy. I use it specifically for fetch and tug, then put it away when we’re done. This keeps it exciting and extends its lifespan. My dog has other chew toys he can use freely throughout the day. This isn’t just another fetch toy—when thoughtful it provides a structured, instinct-satisfying experience that’s mentally enriching and physically engaging. If you have a high-drive or working breed, or a dog who thrives on interactive play, this ring ball is 100% worth it.
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Reviewed in the United States on March 30, 2025

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