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Description
Canine CD8 Mouse mAb (S-422-37)Product Specification Host Mouse Antigen Canine CD8 Synonyms T cell surface glycoprotein CD8 alpha chain Immunogen Synthetic Peptide Location Cell membrane Accession P33706 Clone Number S 422 37 Antibody Type Mouse mAb Isotype IgG2b,k Application ELISA Reactivity Dg Purification Protein A Concentration 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0. 03% Proclin 300 Stability & Storage 12
Product Specification
| Host | Mouse |
| Antigen | Canine CD8 |
| Synonyms | T-cell surface glycoprotein CD8 alpha chain |
| Immunogen | Synthetic Peptide |
| Location | Cell membrane |
| Accession | P33706 |
| Clone Number | S-422-37 |
| Antibody Type | Mouse mAb |
| Isotype | IgG2b,k |
| Application | ELISA |
| Reactivity | Dg |
| Purification | Protein A |
| Concentration | 5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Background
CD8 is a transmembrane glycoprotein that serves as a co-receptor for the T-cell receptor (TCR), playing a crucial role in T cell signaling and aiding cytotoxic T cell-antigen interactions. It binds specifically to the MHC class I protein, enhancing the affinity between the T cell receptor of cytotoxic T cells and target cells during antigen-specific activation. CD8 exists in two isoforms, alpha (CD8A) and beta (CD8B), each encoded by a different gene located on chromosome 2 in humans. The active form of CD8 is a dimer, with three different dimers detected: CD8αα, CD8αβ, and CD8ββ. This co-receptor also plays a role in T cell signaling by binding Lck (lymphocyte-specific protein tyrosine kinase) via its cytoplasmic tail, initiating a cascade of phosphorylation that leads to the activation of transcription factors and affects gene expression.
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