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Description
PSGL-1/CD162 His Tag Protein, HumanProduct Specification Species Human Synonyms Selectin P ligand, P selectin glycoprotein ligand 1, PSGL 1, CD162 Accession Q14242 1 Amino Acid Sequence Gln42 Cys320, with C terminal His Expression System HEK293 Molecular Weight 64 93kDa (Reducing) Purity 95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4. Reconstitution Reconstitute at 0. 1 1 mg ml according to the
Product Specification
| Species | Human |
| Synonyms | Selectin P ligand, P-selectin glycoprotein ligand 1, PSGL-1, CD162 |
| Accession | Q14242-1 |
| Amino Acid Sequence | Gln42-Cys320, with C-terminal His |
| Expression System | HEK293 |
| Molecular Weight | 64-93kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4. |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | Ye Z, Zhong L, Zhu S, Wang Y, Zheng J, Wang S, Zhang J, Huang R. The P-selectin and PSGL-1 axis accelerates atherosclerosis via activation of dendritic cells by the TLR4 signaling pathway. Cell Death Dis. 2019; 10:507. |
Background
PSGL-1, a major selectin ligand on leukocytes, binds P-selectin, E-selectin, and L-selectin under flow conditions. PSGL-1 is a sialomucin of 120 kD that forms disulfide-linked (C320) homodimers. These have two subunits each contain two to three N-glycans, which are critical for P-selectin binding. Each subunit consists of an extracellular, transmembrane, and cytoplasmic domain. PSGL-1 is expressed on most peripheral T cells and on some B cells, neutrophils, monocytes, and platelets. PSGL-1 requires N-terminal tyrosine sulfation for high-affinity P-selectin binding. The PSGL-1 cytoplasmic domain binds ERM proteins, thereby linking PSGL-1 to the actin cytoskeleton. Recently, PSGL-1 has been shown to be of key importance for the delivery of tissue factor to sites of thrombosis. Blocking functional PSGL-1 reduces visceral adipose inflammation and ameliorates endothelial dysfunction in atherosclerosis.
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