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Description
GPRC5D Recombinant Rabbit mAb (S-2169-203)Product Specification Host Rabbit Antigen GPRC5D Synonyms G protein coupled receptor family C group 5 member D Immunogen Synthetic Peptide Location Cell membrane Accession Q9NZD1 Clone Number S 2169 203 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu Positive Sample RPMI 8226, SK MEL 28, HeLa, A431, mouse kidney Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer
Product Specification
| Host | Rabbit |
| Antigen | GPRC5D |
| Synonyms | G-protein coupled receptor family C group 5 member D |
| Immunogen | Synthetic Peptide |
| Location | Cell membrane |
| Accession | Q9NZD1 |
| Clone Number | S-2169-203 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu |
| Positive Sample | RPMI-8226, SK-MEL-28, HeLa, A431, mouse kidney |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:500-1:1000 | Hu, Ms |
Background
GPRC5D (G protein-coupled receptor class C group 5 member D) is a ~40 kDa seven-transmembrane orphan receptor whose natural ligand remains unknown; it carries a very short extracellular N-terminus, forms homodimers via TM4–TM4/5 contacts, and is transcriptionally induced by retinoic acid. In healthy tissues expression is tightly restricted—highest in hair follicle and nail bed keratinocytes where it modulates hard-keratin gene expression—while in malignancy it is markedly up-regulated on the surface of multiple-myeloma plasma cells, rendering it a tumor-selective antigen now exploited by bispecific antibodies (talquetamab, LBL-034) and CAR-T cells that redirect T-cell cytotoxicity against GPRC5D-positive myeloma cells, with minimal on-target toxicity to normal tissues .
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