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Description
HGFR/c-MET His Tag Protein, HumanProduct Specification Species Human Synonyms HGFR, c MET, HGF SF receptor, DFNB97, AUTS9, RCCP2, Hepatocyte growth factor receptor, Tyrosine protein kinase Met Accession P08581 1 Amino Acid Sequence Glu25 Thr932, with C 10*His Expression System HEK293 Molecular Weight 80 90kDa Purity >95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4 Reconstitution Reconstitute at
Product Specification
| Species | Human |
| Synonyms | HGFR, c-MET, HGF/SF receptor, DFNB97, AUTS9, RCCP2, Hepatocyte growth factor receptor, Tyrosine-protein kinase Met |
| Accession | P08581-1 |
| Amino Acid Sequence | Glu25-Thr932, with C-10*His |
| Expression System | HEK293 |
| Molecular Weight | 80-90kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference |
1、Garcia S. et al. (2007) c-Met overexpression in inflammatory breast carcinomas: automated quantification on tissue microarrays. British journal of cancer. 96(2): 329-335. 2、Socoteanu M P. et al. (2008) c-Met targeted therapy of cholangiocarcinoma. World J Gastroenterol. 14(19): 2990-2994. 3、Kong D S. et al. (2009) Prognostic significance of c-Met expression in glioblastomas. Cancer. 115(1): 140-8. 4、McGill GG, et al. (2006) c-Met expression is regulated by Mitf in the melanocyte lineage. J Biol Chem. 281(15): 10365-73. |
Background
HGF R, also known as Met, is a glycosylated receptor tyrosine kinase that plays a central role in epithelial morphogenesis and cancer development. HGF R is synthesized as a single chain precursor which undergoes cotranslational proteolytic cleavage. This generates a mature HGFR that is a disulfide-linked dimer composed of a 50 kDa extracellular alpha chain and a 145 kDa transmembrane beta chain.. The extracellular domain (ECD) contains a seven bladed beta-propeller sema domain, a cysteine-rich PSI/MRS, and four Ig-like E-set domains, while the cytoplasmic region includes the tyrosine kinase domain. HGFR is normally expressed by cells of epithelial origin, while expression of HGF is restricted to cells of mesenchymal origin.
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