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Description
Alexa Fluor® 647 Rat Anti-Mouse CD40 Antibody (S-R456)Product Specification Host Rat Antigen CD40 Synonyms Tumor necrosis factor receptor superfamily member 5; B cell surface antigen CD40; Bp50; CD40L receptor; Tnfrsf5; Cd40 Location Cell membrane Accession P27512 Clone Number S R456 Antibody Type Rat mAb Isotype IgG2a,k Application FCM Reactivity Ms Positive Sample BALB c mouse splenocytes Purification Protein G Concentration 0. 2 mg ml Conjugation Alexa Fluor 647 Physical Appearance Liquid Storage
Product Specification
| Host | Rat |
| Antigen | CD40 |
| Synonyms | Tumor necrosis factor receptor superfamily member 5; B-cell surface antigen CD40; Bp50; CD40L receptor; Tnfrsf5; Cd40 |
| Location | Cell membrane |
| Accession | P27512 |
| Clone Number | S-R456 |
| Antibody Type | Rat mAb |
| Isotype | IgG2a,k |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | BALB/c mouse splenocytes |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | Alexa Fluor® 647 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Ms |
Background
CD40, also known as TNFRSF5, is a type I transmembrane protein and a member of the tumor necrosis factor receptor superfamily, primarily expressed on antigen-presenting cells such as dendritic cells, macrophages, and B cells. Its ligand, CD40L (CD154), is mainly found on activated T cells and is also expressed on platelets, endothelial cells, and smooth muscle cells. The interaction between CD40 and CD40L plays a crucial role in immune regulation, mediating a wide range of immune responses, including B cell proliferation, differentiation, and immunoglobulin class switching, as well as enhancing T cell activation and dendritic cell maturation. This interaction initiates intracellular signaling pathways involving TRAF proteins and leads to the activation of transcription factors such as NF-κB, which in turn regulate cytokine production and immune cell function. CD40 signaling is also implicated in metabolic processes, influencing glucose metabolism and lipid homeostasis, particularly in macrophages and endothelial cells. Dysregulation of the CD40-CD40L pathway is associated with various diseases, including immunodeficiency syndromes and autoimmune disorders.
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