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Description
PRDM1/Blimp1 Recombinant Rabbit mAb (S-1972-3)Product Specification Host Rabbit Antigen PRDM1 Blimp1 Synonyms PR domain zinc finger protein 1; BLIMP 1; Beta interferon gene positive regulatory domain I binding factor; PR domain containing protein 1; Positive regulatory domain I binding factor 1 (PRDI BF1; PRDI binding factor 1) Immunogen Synthetic Peptide Location Cytoplasm, Nucleus Accession O75626 Clone Number S 1972 3 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC
Product Specification
| Host | Rabbit |
| Antigen | PRDM1/Blimp1 |
| Synonyms | PR domain zinc finger protein 1; BLIMP-1; Beta-interferon gene positive regulatory domain I-binding factor; PR domain-containing protein 1; Positive regulatory domain I-binding factor 1 (PRDI-BF1; PRDI-binding factor 1) |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Nucleus |
| Accession | O75626 |
| Clone Number | S-1972-3 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | THP-1, HeLa, A431, RAW264.7, rat colon |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt |
| IHC-P | 1:1000 | Hu, Ms, Rt |
| ICC | 1:500 | Hu, Ms |
Background
PRDM1, also known as Blimp1, is a crucial transcriptional regulator that plays significant roles in various biological processes. It is a zinc finger protein with a complex structure containing multiple functional domains. In the immune system, PRDM1/Blimp1 is essential for the terminal differentiation of B cells into plasma cells, helping to suppress the expression of genes related to B cell proliferation and maintenance of the B cell phenotype, thereby facilitating the transition to plasma cells which are specialized for antibody production. Additionally, it also has important functions in other cell types and developmental contexts, such as influencing the differentiation of certain T cell subsets and participating in the regulation of some developmental processes in tissues like the skin. Its dysregulation has been implicated in various diseases, including certain types of cancers and autoimmune disorders, making it an interesting target for potential therapeutic interventions.
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