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Description
Rictor Recombinant Rabbit mAb (S-2601-26)Product Specification Host Rabbit Antigen Rictor Synonyms Rapamycin insensitive companion of mTOR; AVO3 homolog (hAVO3); KIAA1999; RICTOR Immunogen Synthetic Peptide Location Cell membrane, Endoplasmic reticulum membrane Accession Q6R327 Clone Number S 2601 26 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu, Ms, Rt, Mk Positive Sample SH SY5Y, HeLa, PANC 1, HepG2, NIH 3T3, COS 7 Purification Protein A Concentration 0. 5
Product Specification
| Host | Rabbit |
| Antigen | Rictor |
| Synonyms | Rapamycin-insensitive companion of mTOR; AVO3 homolog (hAVO3); KIAA1999; RICTOR |
| Immunogen | Synthetic Peptide |
| Location | Cell membrane, Endoplasmic reticulum membrane |
| Accession | Q6R327 |
| Clone Number | S-2601-26 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu, Ms, Rt, Mk |
| Positive Sample | SH-SY5Y, HeLa, PANC-1, HepG2, NIH/3T3, COS-7 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Mk |
| IHC-P | 1:200 | Hu, Ms, Rt |
Background
Rictor (rapamycin-insensitive companion of mTOR) is a 1,709-amino-acid, 190 kDa cytosolic scaffold protein that is an obligate core subunit of mTORC2, where it stabilizes the complex and recruits substrates such as AKT, PKCα and SGK1 for phosphorylation by mTOR on key hydrophobic motifs, thereby controlling cell survival, metabolism, cytoskeletal organization, embryonic stem-cell differentiation and lymphatic valve formation, while its frequent overexpression or mutation in cancers links it to tumor growth, invasion and drug resistance.
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