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Description
PIIINP Recombinant Rabbit mAb (SDT-149-57)Product Specification Host Rabbit Antigen PIIINP Synonyms Procollagen III N terminal propeptide Immunogen Recombinant Protein Accession P02461 Clone Number SDT 149 57 Antibody Type Recombinant mAb Application Sandwich ELISA Reactivity Hu Cross Reactivity Does not recognize PINP, Laminin, Collagen IV Purification Protein A Concentration 2 mg ml Purity >95% by HPLC Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS pH7. 4, 0. 03%
Product Specification
| Host | Rabbit |
| Antigen | PIIINP |
| Synonyms | Procollagen III N-terminal propeptide |
| Immunogen | Recombinant Protein |
| Accession | P02461 |
| Clone Number | SDT-149-57 |
| Antibody Type | Recombinant mAb |
| Application | Sandwich ELISA |
| Reactivity | Hu |
| Cross Reactivity | Does not recognize PINP, Laminin, Collagen IV |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Purity | >95% by HPLC |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| Sandwich ELISA | N/A |
Background
Procollagen III N-terminal propeptide (PIIINP) is cleaved from procollagen III during collagen synthesis. Thus, circulating PIIINP increases during stimulation of collagen synthesis, and serum-PIIINP can be useful in the diagnosis and monitoring of a range of diseases characterised by increased collagen III deposition. PIIINP as a single marker is currently used in Denmark for monitoring disease activity in scleroderma and methotrexate-induced liver fibrosis. Besides, PIIINP forms part of the Elevated Liver Fibrosis (ELF) test, together with hyaluronic acid and tissue inhibitor of metalloproteinases (TIMP)-1, which has been demonstrated to be sensitive for alcoholic liver fibrosis.
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