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Description
NT-proBNP, HumanProduct Specification Species Human Synonyms NT proBNP; BNF, BNP, brain type natriuretic peptide, Gamma brain natriuretic peptide, natriuretic peptide B, natriuretic peptide precursor B, natriuretic peptides B, natriuretic protein, NPPB Accession P16860 Amino Acid Sequence HHHHHHHPLG SPGSASDLET SGLQEQRNHL QGKLSELQVE QTSLEPLQES PRPTGVWKSR EVATEGIRGH RKMVLYTLRA PR Expression System E. coli Molecular Weight 9. 2 kDa Purity 95%, by SDS PAGE under reducing
Product Specification
| Species | Human |
| Synonyms | NT-proBNP;BNF, BNP, brain type natriuretic peptide, Gamma-brain natriuretic peptide, natriuretic peptide B, natriuretic peptide precursor B, natriuretic peptides B, natriuretic protein, NPPB |
| Accession | P16860 |
| Amino Acid Sequence | HHHHHHHPLG SPGSASDLET SGLQEQRNHL QGKLSELQVE QTSLEPLQES PRPTGVWKSR EVATEGIRGH RKMVLYTLRA PR |
| Expression System | E.coli |
| Molecular Weight | 9.2 kDa |
| Purity | ＞95%, by SDS-PAGE under reducing conditions |
| Endotoxin | <0.2EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS (pH7.2) |
| Reconstitution | Reconstitute at less than 1 mg/mL according to the size in ultrapure water after rapid centrifugation . |
| Stability & Storage | · 12 months from date of receipt, -20 to -70 °C as supplied. |
Background
The N-terminal fragment of pro-brain natriuretic peptide (N-terminal-prohormone Brain Natriuretic Peptide, NT-proBNP), whose molecular weight is 8.5kDa, belongs to the natriuretic peptide family protein, also known as type B brain natriuretic peptide, which has the functions of natriuretic, diuretic, vasodilation and so on. NT-proBNP is mainly synthesized and secreted by ventricular myocytes. Cardiac dysfunction such as high ventricular load and increased wall tension are the main conditions for stimulating NT-proBNP secretion, and the intensity of these stimulating factors is proportional to the content of NT-proBNP. Therefore, NT-proBNP can reflect the changes of ventricular function with strong specificity and high sensitivity, is a very important clinical marker of heart failure, and plays an irreplaceable role in early heart failure screening, prognosis evaluation and so on.
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