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Description
EBOV Envelope (subtype Zaire, strain Kikwit-95) Glycoprotein 1(GP1) His Tag Protein, Ebola virusProduct Specification Species Ebola virus Synonyms EBOV Envelope Glycoprotein 1,Glycoprotein 1,GP1 (EBOV),Ebolavirus EBOV (subtype Zaire,strain Kikwit 95) Envelope Glycoprotein 1 (GP1) Accession P87666 Amino Acid Sequence Ile33 Arg501 with a polyhistidine tag at the C terminus Expression System HEK293 Molecular Weight 80 120 kDa(Reducing) Purity 90% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized
Product Specification
| Species | Ebola virus |
| Synonyms | EBOV Envelope Glycoprotein 1,Glycoprotein 1,GP1 (EBOV),Ebolavirus EBOV (subtype Zaire,strain Kikwit-95) Envelope Glycoprotein 1 (GP1) |
| Accession | P87666 |
| Amino Acid Sequence | Ile33-Arg501 with a polyhistidine tag at the C-terminus |
| Expression System | HEK293 |
| Molecular Weight | 80-120 kDa(Reducing) |
| Purity | ＞90% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | PBS PH7.4 5% trehalose |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | Sanchez A, Trappier SG, Mahy BW, Peters CJ, Nichol ST. The virion glycoproteins of Ebola viruses are encoded in two reading frames and are expressed through transcriptional editing. Proc Natl Acad Sci U S A. 1996 Apr 16;93(8):3602-7. |
Background
The Ebola virus (EBOV) encodes seven structural proteins: nucleoprotein (NP), polymerase cofactor (VP35), matrix protein (VP40), glycoprotein (GP), transcription activator (VP30), VP24, and RNA polymerase (L). The GP protein comprises a 160-kDa envelope-attached glycoprotein (GP) and a 110-kDa secreted glycoprotein (sGP). GP is a class I fusion protein that assembles as trimers on the viral surface, playing a crucial role in virus entry and attachment. The mature GP is a disulfide-linked heterodimer formed by two subunits, GP1 and GP2, generated from the proteolytic processing of the GP precursor (pre-GP) by cellular furin during virus assembly. GP1 binds to receptors on target cells and interacts with CD209/DC-SIGN and CLEC4M/DC-SIGNR, which serve as cofactors for virus entry into the host cell.
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