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Description
DLAT Rabbit Polyclonal AntibodyProduct Specification Host Rabbit Antigen DLAT Synonyms Dihydrolipoyllysine residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial; 70 kDa mitochondrial autoantigen of primary biliary cirrhosis (PBC); Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; M2 antigen complex 70 kDa subunit; Pyruvate dehydrogenase complex component E2 (PDC E2; PDCE2); DLTA Immunogen Synthetic Peptide Location
Product Specification
| Host | Rabbit |
| Antigen | DLAT |
| Synonyms | Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial; 70 kDa mitochondrial autoantigen of primary biliary cirrhosis (PBC); Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; M2 antigen complex 70 kDa subunit; Pyruvate dehydrogenase complex component E2 (PDC-E2; PDCE2); DLTA |
| Immunogen | Synthetic Peptide |
| Location | Mitochondrion |
| Accession | P10515 |
| Antibody Type | Polyclonal antibody |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | HeLa, HepG2, LNCaP, A431, NIH/3T3, mouse brain, C6, rat brain |
| Purification | Immunogen Affinity |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt |
| IHC-P | 1:200-1:500 | Hu, Ms, Rt |
Background
Dihydrolipoamide S-acetyltransferase (DLAT) is a key component of the pyruvate dehydrogenase complex (PDC), which is located in the mitochondria. This enzyme plays a crucial role in cellular energy production by facilitating the conversion of pyruvate into acetyl-CoA, a process that links glycolysis to the citric acid cycle. DLAT accepts acetyl groups formed by the oxidative decarboxylation of pyruvate and transfers them to coenzyme A (CoA). It is encoded by the DLAT gene, which is conserved across various species. Mutations in this gene can lead to pyruvate dehydrogenase E2 deficiency, causing primary lactic acidosis in infancy and early childhood. Additionally, DLAT is the antigen for antimitochondrial antibodies, which are present in nearly 95% of patients with primary biliary cirrhosis (PBC), an autoimmune liver disease.
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