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Description
Erk1/2 Recombinant Rabbit mAb (S-3178)Product Specification Host Rabbit Antigen Erk1 2 Synonyms Mitogen activated protein kinase 1; MAP kinase 1; MAPK 1; ERT1; Extracellular signal regulated kinase 2 (ERK 2); MAP kinase isoform p42 (p42 MAPK); Mitogen activated protein kinase 2 (MAP kinase 2; MAPK 2); ERK2; PRKM1; PRKM2; MAPK1 Location Cytoplasm, Cytoskeleton, Nucleus Accession P28482 Clone Number S 3178 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Hu,
Product Specification
| Host | Rabbit |
| Antigen | Erk1/2 |
| Synonyms | Mitogen-activated protein kinase 1; MAP kinase 1; MAPK 1; ERT1; Extracellular signal-regulated kinase 2 (ERK-2); MAP kinase isoform p42 (p42-MAPK); Mitogen-activated protein kinase 2 (MAP kinase 2; MAPK 2); ERK2; PRKM1; PRKM2; MAPK1 |
| Location | Cytoplasm, Cytoskeleton, Nucleus |
| Accession | P28482 |
| Clone Number | S-3178 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | HeLa, K562, Daud, HepG2, U-87 MG, PC-3, NIH/3T3, C6 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:5000 | Hu, Ms, Rt, Mk |
| IHC-P | 1:500 | Hu, Ms, Rt |
| ICC | 1:500 | Hu |
Background
Erk1/2 proteins, also known as extracellular signal-regulated kinases 1 and 2, are key components of the MAPK (mitogen-activated protein kinase) signaling pathway. They play roles crucial in regulating various cellular processes such as cell proliferation, differentiation, survival, and apoptosis. Erk1/2 can be activated by a wide range of extracellular stimuli including growth factors, cytokines, and hormones. Once activated, they phosphorylate a cascade of downstream targets, thereby transmitting signals from the cell surface to the nucleus and modulating gene expression. Dysregulation of Erk1/2 signaling has been implicated in numerous diseases, including cancer andde neurogenerative disorders, making them important targets for therapeutic intervention.
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