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Description
APC6 Recombinant Rabbit mAb (S-2550-48)Product Specification Host Rabbit Antigen APC6 Synonyms Cell division cycle protein 16 homolog; Anaphase promoting complex subunit 6 (APC6); Cyclosome subunit 6; Anapc6; Cdc16 Immunogen Recombinant Protein Location Cytoplasm, Nucleus Accession Q8R349 Clone Number S 2550 48 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Hu, Ms, Rt Positive Sample NIH 3T3, mouse liver, C6, rat brain Purification Protein A Concentration
Product Specification
| Host | Rabbit |
| Antigen | APC6 |
| Synonyms | Cell division cycle protein 16 homolog; Anaphase-promoting complex subunit 6 (APC6); Cyclosome subunit 6; Anapc6; Cdc16 |
| Immunogen | Recombinant Protein |
| Location | Cytoplasm, Nucleus |
| Accession | Q8R349 |
| Clone Number | S-2550-48 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | NIH/3T3, mouse liver, C6, rat brain |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1: 2000 | Ms, Rt |
| IHC-P | 1:100-1: 1000 | Hu, Ms, Rt |
Background
APC6 (also known as CDC16) is a core scaffolding subunit of the anaphase-promoting complex/cyclosome (APC/C), a multi-subunit E3 ubiquitin ligase that governs cell cycle progression by targeting key regulatory proteins such as cyclins and securin for proteasomal degradation; APC6 contains multiple tetratricopeptide repeats (TPRs) that mediate protein-protein interactions essential for APC/C integrity and is stabilized by the small subunit CDC26, ensuring proper ubiquitin transfer and timely transition from metaphase to anaphase, thereby safeguarding genomic stability.
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