Pay in installments of $42.50 with
,
and
Shipping Estimate
USA
- USA
- CAN
- USA
- CAN
Ships within 48 hours · Estimated delivery Aug 13 - Aug 18
Promo Codes Available:
For Your Every Summer RSVP, with Code: SUMMER15
Description
Alexa Fluor® 647 Rat Anti-Mouse CD223 Antibody (S-R624)Product Specification Host Rat Antigen CD223 Synonyms Lymphocyte activation gene 3 protein; LAG 3; Activation induced cytidine deaminase linked autoimmunity protein (Aida); Lag3 Location Cell membrane Accession Q61790 Clone Number S R624 Antibody Type Rat mAb Isotype IgG1,k Application FCM Reactivity Ms Purification Protein G Concentration mg ml Conjugation Alexa Fluor 647 Physical Appearance Liquid Storage Buffer PBS, 25% Glycerol, 1% BSA, 0. 3%
Product Specification
| Host | Rat |
| Antigen | CD223 |
| Synonyms | Lymphocyte activation gene 3 protein; LAG-3; Activation-induced cytidine deaminase-linked autoimmunity protein (Aida); Lag3 |
| Location | Cell membrane |
| Accession | Q61790 |
| Clone Number | S-R624 |
| Antibody Type | Rat mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Ms |
| Purification | Protein G |
| Concentration | mg/ml |
| Conjugation | Alexa Fluor® 647 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 25% Glycerol, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5 μl per million cells in 100μl volume |
Background
CD223, also known as LAG-3 (lymphocyte activation gene-3), is a type I transmembrane protein belonging to the immunoglobulin (Ig) superfamily. It is expressed on the surface of activated T cells, regulatory T cells (Tregs), natural killer (NK) cells, and some other immune cells. Structurally, it is similar to CD4 and has a higher binding affinity to MHC class II molecules than CD4. LAG-3 primarily functions as an immune checkpoint receptor, negatively regulating T-cell activation, proliferation, and cytokine production. In cancer and chronic infections, elevated LAG-3 expression is associated with T cell exhaustion, limiting anti-tumor and antiviral responses. Due to its significant role in immune regulation, LAG-3 has become a promising target for cancer immunotherapy and the treatment of autoimmune disorders.
Shipping Notes
- Free Standard Shipping on $100+ Orders to the USA.
- Except Preorder products are shipped in 48 hours.
- Delivery to the USA:
- Standard Shipping : 3-10 business days
- If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
- Final sale items are not eligible for returns or exchanges.
- To process your return/exchange, please contact us at [email protected]
- Please click here for more details>>> Return & Exchange Policy