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Description
IGFBP-2 Protein, MouseProduct Specification Species Mouse Synonyms Insulin like growth factor binding protein 2, IBP 2, IGF binding protein 2, IGFBP 2, mIGFBP 2 Accession P47877 Amino Acid Sequence Gln35 Gln305 with His Tag at the C Terminus Expression System HEK293 Molecular Weight 38 40 kDa (Reducing) Purity >95% by SDS PAGE & HPLC. Endotoxin <0. 1EU g Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized powder Storage Buffer PBS, 1mM EDTA, pH7. 4
Product Specification
| Species | Mouse |
| Synonyms | Insulin-like growth factor-binding protein 2, IBP-2, IGF-binding protein 2, IGFBP-2, mIGFBP-2 |
| Accession | P47877 |
| Amino Acid Sequence | Gln35-Gln305 with His Tag at the C-Terminus |
| Expression System | HEK293 |
| Molecular Weight | 38-40 kDa (Reducing) |
| Purity | >95% by SDS-PAGE & HPLC. |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | PBS, 1mM EDTA, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | ·12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | Cell Metab. 2010 Jan;11(1):11-22. |
Background
Insulin-like Growth Factor Binding Protein-2 (IGFBP-2) is a 30–36 kDa secreted protein encoded by the Igfbp2 gene, containing 271 amino acids in the mature form after cleavage of a 34-amino acid signal peptide. Mouse and human IGFBP-2 share approximately 82% homology. IGFBP-2 binds both IGF-I and IGF-II with high affinity, exhibiting 2–10 fold higher affinity for IGF-II than for IGF-I. This binding prolongs IGF half-life and modulates ligand-receptor interactions.
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