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Description
NINJ1 Recombinant Rabbit mAb (S-3109-56)Product Specification Host Rabbit Antigen NINJ1 Synonyms Ninjurin 1; hNINJ1; Nerve injury induced protein 1 Immunogen Synthetic Peptide Location Cell membrane Accession Q92982 Clone Number S 3109 56 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu, Mk Positive Sample HepG2, A549, HeLa, Jurkat, K562, COS 7 Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS,
Product Specification
| Host | Rabbit |
| Antigen | NINJ1 |
| Synonyms | Ninjurin-1; hNINJ1; Nerve injury-induced protein 1 |
| Immunogen | Synthetic Peptide |
| Location | Cell membrane |
| Accession | Q92982 |
| Clone Number | S-3109-56 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu, Mk |
| Positive Sample | HepG2, A549, HeLa, Jurkat, K562, COS-7 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:2000 | Hu, Mk |
| IHC-P | 1:1000 | Hu |
Background
NINJ1, a 16 kDa evolutionary-conserved double-transmembrane protein first discovered as a nerve-injury-induced adhesion molecule, has emerged as the key executioner of plasma-membrane rupture (PMR) downstream of all major lytic cell-death pathways (pyroptosis, apoptosis, necroptosis, ferroptosis, PANoptosis, cuproptosis and parthanatos); upon death stimuli it oligomerizes into amphipathic filaments or “cookie-cutter” rings that breach the lipid bilayer, releasing damage-associated molecular patterns and propagating inflammation, while also regulating leukocyte trafficking, TLR4 signaling and blood–brain-barrier integrity, making it a promising therapeutic target in ischemia, sepsis, neuroinflammation and cancer.
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