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Description
Estrogen Receptor α Recombinant Rabbit mAb (SDT-10001)Product Specification Host Rabbit Antigen Estrogen Receptor Synonyms Estrogen receptor, ER, ER alpha, Estradiol receptor, Nuclear receptor subfamily 3 group A member 1 Location Nucleus Accession P03372 Clone Number SDT 10001 Antibody Type Recombinant mAb Application IHC P Reactivity Hu Purification Protein A Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS 59%, Sodium azide 0. 01%, Glycerol 40%, BSA 0. 05% Stability & Storage 12
Product Specification
| Host | Rabbit |
| Antigen | Estrogen Receptor α |
| Synonyms | Estrogen receptor, ER, ER-alpha, Estradiol receptor, Nuclear receptor subfamily 3 group A member 1 |
| Location | Nucleus |
| Accession | P03372 |
| Clone Number | SDT-10001 |
| Antibody Type | Recombinant mAb |
| Application | IHC-P |
| Reactivity | Hu |
| Purification | Protein A |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05% |
| Stability & Storage |
12 months from date of receipt / reconstitution, -20 °C as supplied
|
Dilution
| application | dilution | species |
| IHC | 1:100-1:200 |
Background
Estrogen receptor (ER) belongs to the steroid receptor superfamily of nuclear receptors. It is a protein with 553 amino acids. The receptor molecule has three domains, i.e. the central DNA-binding domain, the hormone-binding domain at the Cterminal, and the transcription-activating domain at the N-terminal. ER mediates regulatory functions of female sex steroids, mainly 17 (E2), on growth, differentiation and function in several target tissues, including female and male reproductive tract, mammary gland, and skeletal and cardiovascular systems. Studies have shown ER α is present in the nuclei of epithelial cells in normal breast and endometrial tissues, as well as a subset of breast carcinomas. Studies with immunohistochemical assay show that positive steroid hormone status has predicted favourable overall, survival, independently of hormonal treatment. Secondly, ER α can be used as a tumour marker, preferentially in combination with an antibody to progesterone receptor, e.g., in the classification of adenocarcinomas
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