SKU: 79594471885

Histone H3 (tri methyl K4) Recombinant Rabbit mAb (S-4099)

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Description

Histone H3 (tri methyl K4) Recombinant Rabbit mAb (S-4099)Product Specification Host Rabbit Antigen Histone H3 (tri methyl K4) Synonyms H3K4me3 Location Nucleus Accession P68431 Clone Number S 4099 Antibody Type Recombinant mAb Isotype IgG Application WB, ICC, ChIP Reactivity Hu, Ms, Rt Positive Sample HeLa, NIH 3T3, C6 Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0. 03% Proclin 300 Stability & Storage 12

Product Specification


Host Rabbit
Antigen Histone H3 (tri methyl K4)
Synonyms H3K4me3
Location Nucleus
Accession P68431
Clone Number S-4099
Antibody Type Recombinant mAb
Isotype IgG
Application WB, ICC, ChIP
Reactivity Hu, Ms, Rt
Positive Sample HeLa, NIH/3T3, C6
Purification Protein A
Concentration 0.5 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300

Stability & Storage

12 months from date of receipt / reconstitution, -20°C as supplied

Dilution


application dilution species
WB 1:1000 Hu, Ms, Rt
ICC 1:500 Hu, Ms
ChIP 1:20-1:50 Hu

Background

Histone H3 lysine 4 trimethylation (commonly denoted as H3K4me3) is a crucial epigenetic modification on the tail of core histone H3 that plays a central role in regulating gene transcription. It is primarily catalyzed by histone methyltransferases from the COMPASS/COMPASS-like family (such as MLL1-4 and SET1A/B) and is specifically recognized by "reader" proteins containing PHD domains (e.g., Taf3 and ING family proteins). The genomic distribution of H3K4me3 is highly characteristic: it is strongly enriched at the promoter regions of actively transcribed genes, particularly near transcription start sites, marking a "primed for activation" state. This modification facilitates the formation of open chromatin structures and the assembly of the transcription initiation complex by recruiting chromatin remodelers, general transcription factors, and histone acetyltransferases, thereby positively regulating gene expression. H3K4me3 is essential for maintaining pluripotency in embryonic stem cells, cell fate determination, and processes such as learning and memory. Notably, its dysregulation—whether excessive or deficient—is closely associated with various developmental disorders and cancers (such as leukemia and breast cancer). Consequently, H3K4me3 is not only a vital biomarker in fundamental research but also a potential target for disease diagnosis and therapy.

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SKU: 79594471885

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4.3 ★★★★★
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Northeast OH
Lexington, US
★★★★★ 5
great waterproof cell phone case.
needed a waterproof case for my cell phone when working Emergency Communications with my Amateur Radio equipment and it's raining or snowing. This should work well to protect my cell phone. Zipper seems are sealed really well. Tested the case using sink prior to using with a cell phone.
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Reviewed in the United States on March 31, 2025
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Harley
Lexington, US
★★★★★ 5
Well made and air tight
Love the little pouch it comes in handy for camping,hunting and fishing if your in not so great weather. Not sure how the zipper is made but it's definitely air tight and can feel the difference when sealed. The zipper is a little tough opening and closing but that's probably due to the nature of it being waterproof. Hope it stays that way after long term use!
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Reviewed in the United States on September 28, 2024
M
Verified Purchase
M&Ms
Los Angeles, US
★★★★★ 4
Nice pouch with a small opening
This is a nice weatherproof pouch. It has enough slots for storage of small items like pen/pencil, small notebook, a bootable USB key (for emergency), and I have a fire starting kit in there. It is well built, and I really like the materials used for this pouch. The design though, is less than stellar. One thing, and this is a major issue for me, is that the zipper only opens at the top section of the pouch. I wish it opened more so it is easier to put things in and out of this. But I do understand that it is by design that they selected such a short zipper to keep it as weather proof as possible. The larger the zipper, the higher the likelihood of water leaking into the pouch. Aside from that major issue, I do like the pouch, and I use it in my EDC bag. If I need to replace this for some reason or another, I probably will not be buying this one again. I suspect that this will last a long time though. Hope this helps.
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Reviewed in the United States on June 18, 2025
B
Verified Purchase
Brendan
Los Angeles, US
★★★★★ 5
Awesome
works great, I work wildland fire and am constantly covered in dirt and grim, sometimes even rain and this kept all my gear dry and clean!
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Reviewed in the United States on October 16, 2025
B
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Billy W. Clabough
Phoenix, US
★★★★★ 3
dimensions are wrong
The dimensions listed in title are wrong. It is 4.5" x 7" x 1.625"
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Reviewed in the United States on March 3, 2026

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