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Description
IKKβ Recombinant Rabbit mAb (S-1147-227)Product Specification Host Rabbit Antigen IKK Synonyms Inhibitor of nuclear factor kappa B kinase subunit beta; I kappa B kinase beta; IKK B; IKK beta; IkBKB; I kappa B kinase 2 1 publication; IKK 2 1; IKK2 1 publication; Nuclear factor NF kappa B inhibitor kinase beta (NFKBIKB); Serine threonine protein kinase IKBKB Immunogen Synthetic Peptide Location Cytoplasm, Nucleus Accession O14920 Clone Number S 1147 227 Antibody Type Recombinant mAb Isotype
Product Specification
| Host | Rabbit |
| Antigen | IKKβ |
| Synonyms | Inhibitor of nuclear factor kappa-B kinase subunit beta; I-kappa-B-kinase beta; IKK-B; IKK-beta; IkBKB; I-kappa-B kinase 2 1 publication; IKK-2 1; IKK2 1 publication; Nuclear factor NF-kappa-B inhibitor kinase beta (NFKBIKB); Serine/threonine protein kinase IKBKB |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Nucleus |
| Accession | O14920 |
| Clone Number | S-1147-227 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | HeLa, K562, Jurkat, NIH/3T3, PC-12 |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt |
Background
IKKβ, also known as IκB kinase β or IKK2, is a key regulatory kinase responsible for the activation of NF-κB through phosphorylation at specific serine residues. It is a crucial component of the IKK complex, which includes IKKα, IKKβ, and the regulatory subunit IKKγ (NEMO). Dysregulation of IKKβ activity has been implicated in several cancer types, where it contributes to cancer cell survival, proliferation, invasion, angiogenesis, and metastasis. Targeting IKKβ has emerged as a promising strategy for cancer therapy, with several inhibitors being developed and some advancing to clinical trials.
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