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Description
SOX11 Recombinant Mouse mAb ,PBS Only(SDT-919-58)Product Specification Host Mouse Antigen SOX11 Synonyms Transcription factor SOX 11 Immunogen Synthetic Peptide Location Nucleus Accession P35716 Clone Number SDT 919 58 Antibody Type Mouse mAb Isotype IgG1,k Application WB, IHC P Reactivity Hu Positive Sample SH SY5Y, IMR 32 Predicted Reactivity Ms, Rt Purification Protein G Concentration 2 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS Stability & Storage 12 months from
Product Specification
| Host | Mouse |
| Antigen | SOX11 |
| Synonyms | Transcription factor SOX-11 |
| Immunogen | Synthetic Peptide |
| Location | Nucleus |
| Accession | P35716 |
| Clone Number | SDT-919-58 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | WB, IHC-P |
| Reactivity | Hu |
| Positive Sample | SH-SY5Y, IMR-32 |
| Predicted Reactivity | Ms, Rt |
| Purification | Protein G |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS |
| Stability & Storage | 12 months from date of receipt / reconstitution, 4 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
| IHC-P | 1:1000 | Hu |
Background
SOX11 is a 46.7 kDa nuclear transcription factor of the SOX-C family, encoded by the intronless SOX11 gene at 2p25.3, that contains an N-terminal high-mobility-group DNA-binding domain and a C-terminal transactivation domain; during embryogenesis it is transiently expressed in neuronal progenitors and mesenchymal cells, where it drives proliferation, survival, migration and dendritic morphogenesis of neural precursors via direct targets such as Tuj1 and Tead2, while haploinsufficiency causes Coffin–Siris syndrome with intellectual disability and microcephaly, and in adults its aberrant re-expression is a highly specific marker and oncogenic driver in >90 % of mantle cell lymphomas—both cyclin D1-positive and negative—by promoting B-cell receptor signaling, blocking plasma-cell differentiation and enhancing chemo-sensitivity through interaction with SAMHD1, and it additionally exerts context-dependent tumor-promoting roles in head-and-neck, breast and lung cancers .
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