SKU: 80487338287

Phospho-TAK1 (Ser412) Recombinant Rabbit mAb (S-3334-138)

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Description

Phospho-TAK1 (Ser412) Recombinant Rabbit mAb (S-3334-138)Product Specification Host Rabbit Antigen Phospho TAK1 (Ser412) Synonyms Mitogen activated protein kinase kinase kinase 7; Transforming growth factor beta activated kinase 1 (TGF beta activated kinase 1); TAK1; MAP3K7 Immunogen Synthetic Peptide Location Cytoplasm, Cell membrane Accession O43318 Clone Number S 3334 138 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu, Ms, Rt, Mk Positive Sample HeLa (treated with 100 nM Calyculin

Product Specification


Host Rabbit
Antigen Phospho-TAK1 (Ser412)
Synonyms Mitogen-activated protein kinase kinase kinase 7; Transforming growth factor-beta-activated kinase 1 (TGF-beta-activated kinase 1); TAK1; MAP3K7
Immunogen Synthetic Peptide
Location Cytoplasm, Cell membrane
Accession O43318
Clone Number S-3334-138
Antibody Type Recombinant mAb
Isotype IgG
Application WB
Reactivity Hu, Ms, Rt, Mk
Positive Sample HeLa (treated with 100 nM Calyculin A for 10 minutes and 20 ng/ml human IL-1ß for 10 minutes), K562, C2C12, C6, COS-7
Purification Protein A
Concentration 2 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
Stability & Storage

12 months from date of receipt / reconstitution, -20 °C as supplied

Dilution


application dilution species
WB 1:1000 Hu, Ms, Rt, Mk

Background

Phospho-TAK1 (Ser412) is the activated form of transforming growth factor-β-activated kinase 1 (TAK1, also known as MAP3K7) following phosphorylation at serine residue 412, representing the activation state of this serine/threonine kinase signaling pathway. Ser412 is located within the activation loop region of TAK1, and its phosphorylation is critical for TAK1 kinase activity. When cells are stimulated by inflammatory cytokines (such as IL-1β, TNF-α), TGF-β, or various stress signals, TAK1 is activated through ubiquitination-dependent mechanisms. Phosphorylation at Ser412 promotes the interaction of TAK1 with its cofactors TAB1/TAB2/TAB3, subsequently activating downstream NF-κB and MAPK (including JNK and p38) signaling pathways, thereby regulating diverse biological processes such as inflammatory responses, apoptosis, autophagy, and fibrosis. Studies have shown that aberrant phosphorylation at Ser412 is closely associated with sustained activation of TAK1 in autoimmune diseases, inflammatory bowel disease, liver fibrosis, and various cancers.

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SKU: 80487338287

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4.2 ★★★★★
Based on 18 reviews
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Product Reviews
R
Rob Colvil
Chelsea, US
★★★★★ 5
Became my dog's new favorite
Color: Blue
This instantly became my dog's go-to toy, and thankfully it's lasted longer than I anticipated. He was excited to play with it immediately, of course, but he also continued to go to it over all the other toys he has. He loves to rip and tear, so I didn't think this would last more than a day, but incredibly it's been going for weeks. Granted, he's torn out the squeaker and some of the crinkly plastic, as well as most of the stuffing, but there's still a recognizable dinosaur-shaped toy hanging around that he still likes to play with. The squeaker is also different than most dog toys, it's larger and lower-pitched, so that variation is fun. There's lots of crinkly plastic in the tail and feet, so even after my dog ripped open the tail and gotten that plastic out, there's still more noise-making stuff left in there. The size and amount of stuffing is also great, as it's given him many days of things to tear apart.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on August 21, 2025
S
Susan Bewley
Chelsea, US
★★★★★ 5
My Dogs Love It!
Color: Blue, Color: Blue
Do your dogs love a specific type of toy? Since my girls were puppies, they have preferred a specific material for toys. It is a soft, bubbly texture, usually in bright colors. It is soft for them and durable enough to survive even the toughest of playmates. All the toys made from this material also have a certain crinkle paper that drives both of my girls wild, and sometimes even include a squeaker. When I saw that this adorable dinosaur fit their favorite toy's qualities, I knew I had to get it for them! First, I want to talk about the quality. This dinosaur is adorable and designed for some tough play sessions. It is more reinforced than the name-brand toys I buy, which impressed me. While my girls rarely destroy toys, I find comfort in knowing that they will likely get bored with a toy before destroying it. What shocked me more was the squeaker. This company didn't go cheap; they went for a higher quality, large squeaker that is very loud and durable. My dogs have been playing with this for nearly two hours straight, and the squeaker has been going strong. If you don't like loud squeakers, though, be warned, it is very loud and isn't stop working anytime soon! Overall, this toy has been a big hit and way cheaper than what I can buy at local pet stores. With the quality and how much my girls love it, it has been a bargain and well worth it! This is a toy that we will be purchasing more of soon.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on August 9, 2025
S
StacyP
New York, US
★★★★★ 5
Rawr!
Color: Blue, Color: Blue
My dogs love this toy; they have been playing with it for a few days, and surprisingly, it has been durable enough to withstand most of the torture. it has a fun squeaker and thankfully not too much filler, which I am thankful to have to follow behind to pick up. This is a good value toy. My dogs can usually tear a toy up in seconds but for some reason, they have chosen to keep this dinosaur alive!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on August 18, 2025
S
snowyh
New York, US
★★★★★ 4
Not for Aggressive Chewers
Color: Blue, Color: Blue
Cute stuffed dino with one large squeaker in the body and crinkle paper in the feet and tail. The right size for medium to large dogs. Riley was eager to play tug-of-war with this toy when I first gave it to her. Five minutes later the novelty had worn off and she went to her toy basket to bring out her usual favorites. Being plush, this is not really a toy for aggressive chewers--after only 5 minutes she had torn open a seam and ripped off part of the tag. I'll continue to let her play with it until stuffing starts coming out (which shouldn't be long).
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on August 13, 2025
L
Verified Purchase
Literally doesn’t work
Dallas, US
★★★★★ 5
Great Value Toy
Color: Crinkle Duck (Blue), Size: Large, Color: Crinkle Duck (Blue), Size: Large
This toy has been one of my dog’s absolute favorites. He gets excited every time he sees it and will carry it around the house, toss it in the air, and keep himself entertained for a long time. The shape and texture seem perfect for him, and it quickly became one of his go-to toys over everything else in his basket. What I really like is that it holds up reasonably well for the price. It’s definitely not indestructible, and after a lot of play, it will sometimes start to rip—usually around the feet first since that’s where my dog tends to grab and chew the most. But honestly, considering how affordable it is, I don’t mind replacing it when needed. It’s inexpensive enough that rebuying feels worth it because he genuinely loves it that much. I’d rather keep buying a toy he is obsessed with than spend more on something that just sits untouched. It’s fun, cute, and keeps him happy, which is what matters most. Overall, I’d definitely recommend it for dogs who love plush toys and playful chewing.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 28, 2026

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