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Description
Alexa Fluor® 647 Rat Anti-Mouse CD107a Antibody (S-R668)Product Specification Host Rat Antigen CD107a Synonyms Lysosome associated membrane glycoprotein 1; LAMP 1; Lysosome associated membrane protein 1; 120 kDa lysosomal membrane glycoprotein; CD107 antigen like family member A; LGP 120; Lysosomal membrane glycoprotein A (LGP A); P2B; Lamp1 Location Cell membrane Accession P11438 Clone Number S R668 Antibody Type Rat mAb Isotype IgG2a,k Application FCM Reactivity Ms Positive Sample Fresh C57BL 6 mouse
Product Specification
| Host | Rat |
| Antigen | CD107a |
| Synonyms | Lysosome-associated membrane glycoprotein 1; LAMP-1; Lysosome-associated membrane protein 1; 120 kDa lysosomal membrane glycoprotein; CD107 antigen-like family member A; LGP-120; Lysosomal membrane glycoprotein A (LGP-A); P2B; Lamp1 |
| Location | Cell membrane |
| Accession | P11438 |
| Clone Number | S-R668 |
| Antibody Type | Rat mAb |
| Isotype | IgG2a,k |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | Fresh C57BL/6 mouse peritoneal exudates cells |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | Alexa Fluor® 647 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Ms |
Background
CD107a (also known as lysosome-associated membrane protein-1, LAMP-1) is a heavily N- and O-glycosylated type I transmembrane glycoprotein (~120 kDa) that constitutes ~50% of lysosomal membrane proteins and is expressed constitutively in late endosomes/lysosomes but also transiently on the plasma membrane of degranulating cytotoxic T cells, NK cells, mast cells, and other activated cells, where it serves as a widely used functional marker of degranulation; it participates in lysosomal biogenesis, autophagy, cholesterol homeostasis, and the presentation of carbohydrate ligands to selectins, while its surface exposure correlates with cytotoxic activity and it has been implicated in cancer metastasis, adhesion of immune cells to vascular endothelium, and as a marker in lysosomal storage disorders.
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