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Description
NimacimabProduct Specification Synonyms Namacizumab, Nimacimab (USAN), JNJ 2463, RYI 018 Concentration 95% by SDS PAGE & SEC HPLC Expression System CHO Molecular Weight 25 30kDa&45 55kDa (Reducing) Endotoxin <1EU g Conjugation Unconjugated Physical Appearance Lyophilized Powder Storage Buffer PBS, PH7. 4, 5% trehalose5% mannitol Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water after rapid centrifugation. Stability & Storage
Product Specification
| Synonyms | Namacizumab, Nimacimab (USAN), JNJ-2463, RYI-018 |
| Concentration | ＞95% by SDS-PAGE & SEC-HPLC |
| Expression System | CHO |
| Molecular Weight | 25-30kDa&45-55kDa (Reducing) |
| Endotoxin | <1EU/μg |
| Conjugation | Unconjugated |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, PH7.4, 5% trehalose，5% mannitol |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1. Resat Cinar,et al.The therapeutic potential of second and third generation CB1R antagonists,Pharmacology & Therapeutics,Volume 208,2020,107477,ISSN 0163-7258. |
Background
Nimacimab is a first of its kind humanized monoclonal antibody targeting the cannabinoid 1 receptor ("CB1")that acts as a negative allosteric modulator to inhibit peripheral CB1 signaling. Inhibition of CB1 has shown anti-fibrotic, anti-inflammatory, and metabolic mechanisms of action, and has the potential to address a wide range of diseases with significant unmet medical needs, such as obesity, chronic kidney disease, and non-alcoholic steatohepatitis (NASH).
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