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Description
Biotinylated Ephrin-A3 Fc&Avi Tag Protein, HumanProduct Specification Species Human Synonyms Ephrin A3, EFL 2, EHK1 L, LERK 3, EFNA3 Accession P52797 1 Amino Acid Sequence Gln23 Ser213, with C terminal hIgG1 Fc and Avitag Expression System HEK293 Molecular Weight 60 70kDa (Reducing) Purity 95% by SDS PAGE Endotoxin <1EU g Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4. Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water after rapid centrifugation.
Product Specification
| Species | Human |
| Synonyms | Ephrin-A3, EFL-2, EHK1-L, LERK-3, EFNA3 |
| Accession | P52797-1 |
| Amino Acid Sequence | Gln23-Ser213, with C-terminal hIgG1 Fc and Avitag |
| Expression System | HEK293 |
| Molecular Weight | 60-70kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4. |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1. Keith K. Murai, Louis N. Nguyen, Fumitoshi Irie, Yu Yamaguchi & Elena B. Pasquale: Control of hippocampal dendritic spine morphology through ephrin-A3/EphA4 signaling, Nature Neuroscience volume 6, pages153–160 (2003). |
Background
Eph receptors compose the largest family of receptor tyrosine kinases (RTKs), which are capable of recognizing signals from the cell environment and influencing cell-cell interaction and cell migration. Ephrins are the ligands to Eph receptors and they stimulate bi-directional signaling of the Eph-ephrin axis. Ephrin-A3 (EFNA3) is one of the ephrin ligands which could bind to EphA2, EphA3, EphA5, EphA7, EphA8 and more poorly to EphA4. It is not only expressed in skeletal muscle, spleen, thymus, prostate, testis, ovary, small intestine and peripheral blood leukocytes, but is also present in neuroblastomas, neural cancers and leukemias. The dysregulated expression of EFNA3 has been observed in many types of human cancer. The expression level of EFNA3 was found to be upregulated 26-fold in squamous cell lung carcinoma, 3.8-fold in liver cancer, 1.6-fold in colon cancer and downregulated 2.6-fold in kidney carcinoma, respectively.
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