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Description
M-Cadherin/Cadherin 15 Recombinant Rabbit mAb (S-2261-74)Product Specification Host Rabbit Antigen M Cadherin Cadherin 15 Synonyms Cadherin 15; Cadherin 14; Muscle cadherin (M cadherin); Cdh14; Cdh15 Immunogen Recombinant Protein Location Cell membrane Accession P33146 Clone Number S 2261 74 Antibody Type Recombinant mAb Isotype IgG Application WB, ICC Reactivity Ms Positive Sample C2C12 Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS,
Product Specification
| Host | Rabbit |
| Antigen | M-Cadherin/Cadherin 15 |
| Synonyms | Cadherin-15; Cadherin-14; Muscle cadherin (M-cadherin); Cdh14; Cdh15 |
| Immunogen | Recombinant Protein |
| Location | Cell membrane |
| Accession | P33146 |
| Clone Number | S-2261-74 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, ICC |
| Reactivity | Ms |
| Positive Sample | C2C12 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Ms |
| ICC | 1:500 | Ms |
Background
M-Cadherin (Cadherin-15), a classical calcium-dependent cell-adhesion glycoprotein, is primarily expressed in developing skeletal muscle, satellite cells and cerebellum, where it mediates homophilic binding to organize myoblast fusion, muscle fiber formation and neuronal layer integrity by assembling adherens junctions through catenin-dependent linkage to the actin cytoskeleton ; despite its name, germline deletion in mice is largely compensated by N-cadherin, yet human mutations causing loss of adhesive function are linked to autosomal-dominant mental retardation-3, underscoring a non-redundant role in synaptic and cognitive development .
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