SKU: 82283611912

ALK Recombinant Rabbit mAb,PBS Only (SDT-3284)

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Description

ALK Recombinant Rabbit mAb,PBS Only (SDT-3284)Product Specification Host Rabbit Antigen ALK Synonyms ALK tyrosine kinase receptor; Anaplastic lymphoma kinase; CD246 Location Cell membrane Accession Q9UM73 Clone Number SDT 3284 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu Positive Sample SH SY5Y, IMR 32 Purification Protein A Concentration 1mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS Stability & Storage 12 months from date of

Product Specification


Host Rabbit
Antigen ALK
Synonyms ALK tyrosine kinase receptor; Anaplastic lymphoma kinase; CD246
Location Cell membrane
Accession Q9UM73
Clone Number SDT-3284
Antibody Type Recombinant mAb
Isotype IgG
Application WB, IHC-P
Reactivity Hu
Positive Sample SH-SY5Y, IMR-32
Purification Protein A
Concentration 1mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS

Stability & Storage

12 months from date of receipt / reconstitution, 4 °C as supplied

Dilution


application dilution species
WB 1:1000 Hu
IHC-P 1:250 Hu

Background

Anaplastic lymphoma kinase (ALK), also designated CD246, is a single-pass transmembrane receptor tyrosine kinase of the insulin-receptor superfamily that is normally expressed at highest levels in the developing and adult nervous system, where it regulates neuronal differentiation, axon guidance and cognition; the 1620-aa glycoprotein presents an N-terminal extracellular region containing two MAM domains and an LDL-A module for ligand binding, a single hydrophobic transmembrane segment and a C-terminal cytoplasmic kinase domain that, upon ligand-induced dimerization, undergoes trans-autophosphorylation and triggers RAS–MAPK, PI3K–AKT and JAK–STAT signaling cascades controlling cell proliferation and survival. Chromosomal translocations (most famously t(2;5)(p23;q35) producing NPM1–ALK), inversions (EML4–ALK in non-small-cell lung cancer) or activating point mutations cause constitutive kinase activity, driving malignant transformation in anaplastic large-cell lymphoma, subsets of NSCLC, neuroblastoma and inflammatory myofibroblastoma, making the oncoprotein a validated therapeutic target for small-molecule inhibitors such as crizotinib, alectinib and lorlatinib.

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SKU: 82283611912

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★★★★★ 5
Best pimple patches for calming irritation!
These are my FAVORITE pimple patches. They effectively absorb any extra moisture or gunk coming from my pimples, and the centella in them helps relieve irritation. These have thinner edges, which helps them adhere well to your face, and they stay put all day when I wear them out, or all night when I sleep with them on. I have a cat who likes to smack my face with his all night long and they stay on through his barrage.
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Reviewed in the United States on December 28, 2025
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Mari
Port Orchard, US
★★★★★ 5
Great product for sensitive skin
These are gentle I really like them! Moisturizing is the having secret to treating blemishes. I highly recommend them and I would buy it again.
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Reviewed in the United States on January 21, 2026
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Tiffany Lopez
Massapequa, US
★★★★★ 5
Barely noticeable
I like that these are almost completely invisible on the skin instead of like other patches where they are clear to see
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Reviewed in the United States on January 19, 2026
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Ms. Mullen
Port Orchard, US
★★★★★ 5
Best acne spot patches!
The best ace patches! I first bought them on a trip to Japan, and was using them sparingly until I ran out. They came fast and are about the same price as in Japan. Would absolutely recommend!
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Reviewed in the United States on October 7, 2025
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Brooklyn
Draper, US
★★★★★ 5
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Color: Orange & Blue Roller, Size: 7.5 inches (1 Pack), Color: Orange & Blue Roller, Size: 7.5 inches (1 Pack)
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Reviewed in the United States on March 24, 2026

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