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Description
MICA Fc Chimera Protein, HumanProduct Specification Species Human Synonyms MHC Class I Polypeptide Related Sequence A; MIC A; PERB11. 1 Accession Q29983 1 Amino Acid Sequence Glu24 Gln308, with C terminal Fc Expression System HEK293 Molecular Weight 80 95kDa (Reducing) Purity >95% by SDS PAGE & SEC HPLC Endotoxin <0. 1EU g Conjugation Unconjugated Tag Human IgG1 Fc Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4, 5% trehalose Reconstitution Reconstitute at 0. 1 1
Product Specification
| Species | Human |
| Synonyms | MHC Class I Polypeptide-Related Sequence A; MIC-A; PERB11.1 |
| Accession | Q29983-1 |
| Amino Acid Sequence | Glu24-Gln308, with C-terminal Fc |
| Expression System | HEK293 |
| Molecular Weight | 80-95kDa (Reducing) |
| Purity | >95% by SDS-PAGE & SEC-HPLC |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | Human IgG1 Fc |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | Journal List J Immunother Cancer v.7; 2019 |
Background
MICA is a protein of 383 amino acids and interacts with the NKG2D receptor and the T cell receptor (TCR) to activate NK cells, αβ CD8 T cells, and γδ T cells. MICA is absent from most cells but is frequently expressed in epithelial tumors and can be induced by bacterial and viral infections. Recognition of MICA by NKG2D results in the activation of cytolytic activity and/or cytokine production by these effector cells. MICA recognition is involved in tumor surveillance, viral infections, and autoimmune diseases.
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