SKU: 83017184523

IL-23 R Fc Chimera Protein, Human

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Description

IL-23 R Fc Chimera Protein, HumanProduct Specification Species Human Synonyms IBD17,IL 23 receptor Accession Q5VWK5 1 Amino Acid Sequence Gly24 Gly355 with hIgG1 Fc at the C Terminus Expression System HEK293 Molecular Weight 90 110kDa (Reducing) Purity 95% by SDS PAGE & HPLC Conjugation Unconjugated Tag Human IgG1 Fc Physical Appearance Lyophilized powder Storage Buffer PBS, PH7. 4, 5% trehalose Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water

Product Specification


Species Human
Synonyms IBD17,IL-23 receptor
Accession Q5VWK5-1
Amino Acid Sequence

Gly24-Gly355 with hIgG1 Fc at the C-Terminus
Expression System HEK293
Molecular Weight

90-110kDa (Reducing)
Purity ＞95% by SDS-PAGE & HPLC
Conjugation Unconjugated
Tag Human IgG1 Fc
Physical Appearance Lyophilized powder
Storage Buffer

PBS, PH7.4, 5% trehalose
Reconstitution

Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage

· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Reference

1.Benson JM, Sachs CW, Treacy G, Zhou H, Pendley CE, Brodmerkel CM, Shankar G, Mascelli MA. Therapeutic targeting of the IL-12/23 pathways: generation and characterization of ustekinumab. Nat Biotechnol. 2011 Jul;29(7):615-24.
2.Hue S, Ahern P, Buonocore S, Kullberg MC, Cua DJ, McKenzie BS, Powrie F, Maloy KJ. Interleukin-23 drives innate and T cell-mediated intestinal inflammation. J Exp Med. 2006 Oct 30;203(11):2473-83.

Background

Interleukin-23 (IL-23) is a heterodimeric cytokine composed of p19 and p40 subunits. Its functional receptor, IL-23R, combines with the IL-12Rβ1 subunit to form a type I cytokine receptor complex. This complex activates the downstream JAK2-STAT3 signaling pathway, regulating the proliferation, differentiation, and secretion of inflammatory factors in immune cells such as T cells and NK cells. It plays a central role in sustaining Th17 cell-mediated inflammatory responses. Clinically, abnormal activation of the IL-23/IL-23R pathway is a key pathogenic mechanism in autoimmune diseases such as psoriasis and inflammatory bowel disease. Additionally, it promotes tumorigenesis within the tumor microenvironment, making it a critical therapeutic target.
Shipping Notes
  • Free Standard Shipping on $100+ Orders to the USA.
  • Except Preorder products are shipped in 48 hours.
  • Delivery to the USA:
  1. Standard Shipping : 3-10 business days
  • If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
  • We offer a 30-day return/exchange service after receiving.
  • Final sale items are not eligible for returns or exchanges.
  • To process your return/exchange, please contact us at [email protected]
  • Please click here for more details>>> Return & Exchange Policy
SKU: 83017184523

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4.5 ★★★★★
Based on 21 reviews
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Product Reviews
R
Verified Purchase
RedOrchid45
Cuba, US
★★★★★ 5
No More Manual Twisting of the Grinders!
Color: 2-Speed Silver, Size: Rechargeable
This is my first time trying this type of product and initially I was a bit skeptical they would be helpful but after using for some time, I find I really like them! I love freshly cracked pepper and salt, but the twisting of the manual grinders was becoming tiresome. This set holds a good amount of peppercorns and the batteries seem to last long. Very easy to use if you learn to pick up without touching the buttons. These do the trick! Great product!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 3, 2026
D
Verified Purchase
DP
Pawtucket, US
★★★★★ 1
Stopped charging one month later.
Color: 2-Speed Silver, Size: Rechargeable
It was great even though it grinds very coarse. It can be adjusted but the finer is still too coarse but that was not a big deal. It has now stopped taking charge at the base and there’s no other way to charge it… since the return window closed, to the trash it goes
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on February 27, 2026
M
Verified Purchase
MJG
Houston, US
★★★★★ 5
Works Very Well
Color: 2-Speed Silver, Size: Rechargeable
At first salt spilled from bottom and top was loose. I then realized there was an adjustment on bottom that took care of that issue and if I put top on until it clicked, it locked. They work very nicely and I would recommend them.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on September 21, 2025
C
Verified Purchase
crystal cintra
Grantham, US
★★★★★ 5
These are great and good quality
Color: 2-Speed Silver, Size: Rechargeable
These are great and good quality
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 23, 2026
R
Verified Purchase
R&S Mick
Boise, US
★★★★★ 5
Convenient set with charging stand and light
Color: 2-Speed Silver, Size: Rechargeable
Recommend for anyone who cooks and wants fresh seasoning with less hassle. The built-in light on the bottom was a pleasant surprise and ends up being genuinely useful. It helps you see exactly where the seasoning is going and how much you’re dispensing, especially when you’re cooking in the evening or working over darker foods. That small detail makes the set feel more practical than a basic grinder.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on March 1, 2026

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