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Description
Alexa Fluor® 647 Rat Anti-Mouse CD31 Antibody (S-2908)Product Specification Host Rat Antigen CD31 Synonyms Platelet endothelial cell adhesion molecule; PECAM 1; Pecam; Pecam1 Location Cell membrane Accession Q08481 Clone Number S 2908 Antibody Type Rat mAb Isotype IgG2a,k Application FCM Reactivity Ms Positive Sample BALB c mouse splenocytes Purification Protein G Concentration 0. 2 mg ml Conjugation Alexa Fluor 647 Physical Appearance Liquid Storage Buffer PBS, 1% BSA, 0. 3% Proclin 300 Stability &
Product Specification
| Host | Rat |
| Antigen | CD31 |
| Synonyms | Platelet endothelial cell adhesion molecule; PECAM-1; Pecam; Pecam1 |
| Location | Cell membrane |
| Accession | Q08481 |
| Clone Number | S-2908 |
| Antibody Type | Rat mAb |
| Isotype | IgG2a,k |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | BALB/c mouse splenocytes |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | Alexa Fluor® 647 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Ms |
Background
CD31, also known as platelet endothelial cell adhesion molecule (PECAM-1), is a glycoprotein encoded by the PECAM1 gene and expressed on endothelial cells, platelets, and various types of leukocytes. It is a type I transmembrane protein with six extracellular immunoglobulin-like domains, a transmembrane segment, and a short cytoplasmic tail. CD31 plays crucial roles in cell-cell adhesion, immune response, and vascular integrity. It facilitates leukocyte transmigration during inflammation, maintains endothelial cell junctions, and regulates vascular permeability. Additionally, CD31 is involved in angiogenesis and has potential implications in cancer metastasis and thrombus formation. Its expression and function are also implicated in various diseases, including atherosclerosis and Alzheimer's disease.
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