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Description
IGFBP2 Recombinant Rabbit mAb (S-808-24)Product Specification Host Rabbit Synonyms Insulin like growth factor binding protein 2, IBP 2, IGF binding protein 2, BP2, IBP2 Immunogen Synthetic Peptide Location Secreted Accession P18065 Clone Number S 808 24 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0. 03% Proclin
Product Specification
| Host | Rabbit |
| Synonyms | Insulin-like growth factor-binding protein 2, IBP-2, IGF-binding protein 2, BP2, IBP2 |
| Immunogen | Synthetic Peptide |
| Location | Secreted |
| Accession | P18065 |
| Clone Number | S-808-24 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | |
| IHC-P | 1:200 |
Background
IGFBP2 is one of six homologous proteins in the IGFBP family. Based on its ability to bind IGFs with high affinity, IGFBP2 can exert its functions by interacting with IGFs in the circulation to control the function and activity of IGFs, and prevent the interaction between IGFs and IGF receptors. Moreover, it can also bind to IGFs and confer an IGF-dependent growth inhibitory or stimulatory effect in many cell types. IGFBP2 also performs IGF-independent roles in cancer development and progression through a variety of molecular networks. Aberrant overexpression of IGFBP2 is associated with an aggressive phenotype of a broad range of human cancers, including glioma, ovarian, prostate, pancreatic, breast, lung, colorectal, melanoma, liver cancer, gastric, rhabdomyosarcoma and leukemia. Moreover, high circulating IGFBP2 levels may serve as a usable diagnostic or prognostic tumor biomarker in many types of cancer, and is closely associated with relapse and a poorer outlook for patients with cancer
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