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Description
VPS18 Recombinant Rabbit mAb (S-2517-69)Product Specification Host Rabbit Antigen VPS18 Synonyms Vacuolar protein sorting associated protein 18 homolog; hVPS18; KIAA1475 Immunogen Synthetic Peptide Location Lysosome, Endosome Accession Q9P253 Clone Number S 2517 69 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu, Ms, Rt Positive Sample HeLa, 293T, K562, A549, HepG2, mouse brain, rat brain Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated
Product Specification
| Host | Rabbit |
| Antigen | VPS18 |
| Synonyms | Vacuolar protein sorting-associated protein 18 homolog; hVPS18; KIAA1475 |
| Immunogen | Synthetic Peptide |
| Location | Lysosome, Endosome |
| Accession | Q9P253 |
| Clone Number | S-2517-69 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | HeLa, 293T, K562, A549, HepG2, mouse brain, rat brain |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt |
| IHC-P | 1:250 | Hu, Ms, Rt |
Background
VPS18 (Vacuolar Protein Sorting 18) is a conserved eukaryotic protein that serves as a core subunit of both the HOPS and CORVET tethering complexes, which mediate membrane docking and fusion events in the late endosomal and lysosomal pathways. It plays a critical role in vesicle trafficking, including endocytosis, autophagy, and lysosome biogenesis. VPS18 contains a RING-finger domain, suggesting E3 ubiquitin ligase activity, and has been implicated in viral replication, neurodegeneration, and tumor suppression through its regulation of receptor degradation and intracellular signaling pathways.
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