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Description
Myelin Basic Protein Recombinant Rabbit mAb (S-582-79)Product Specification Host Rabbit Antigen Myelin Basic Protein Synonyms MBP, Myelin A1 protein, Myelin membrane encephalitogenic protein Immunogen Synthetic Peptide Location Myelin membrane Accession P02686 Clone Number S 582 79 Antibody Type Recombinant mAb Application WB, IHC P, ICFCM, IF Reactivity Hu, Ms, Rt Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0.
Product Specification
| Host | Rabbit |
| Antigen | Myelin Basic Protein |
| Synonyms | MBP, Myelin A1 protein, Myelin membrane encephalitogenic protein |
| Immunogen | Synthetic Peptide |
| Location | Myelin membrane |
| Accession | P02686 |
| Clone Number | S-582-79 |
| Antibody Type | Recombinant mAb |
| Application | WB, IHC-P, ICFCM, IF |
| Reactivity | Hu, Ms, Rt |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:2000 | |
| IHC | 1:4000 | |
| IF | 1:500 | |
| ICFCM | 1:50 |
Background
Myelin basic protein (MBP) is a protein believed to be important in the process of myelination of nerves in the nervous system. The myelin sheath is a multi-layered membrane, unique to the nervous system, that functions as an insulator to greatly increase the velocity of axonal impulse conduction. MBP maintains the correct structure of myelin, interacting with the lipids in the myelin membrane. Interest in MBP has centered on its role in demyelinating diseases, in particular, multiple sclerosis (MS). The target antigen of the autoimmune response in MS has not yet been identified. However, several studies have shown a role for antibodies against MBP in the pathogenesis of MS. Some studies have linked a genetic predisposition to MS to the MBP gene, though a majority have not.
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