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Description
ERG Recombinant Rabbit mAb (SDT-190-65)Product Specification Host Rabbit Antigen ERG Synonyms Transcriptional regulator ERG, Transforming protein ERG Immunogen Synthetic Peptide Location Cytoplasm, Nucleus Accession P11308 Clone Number SDT 190 65 Antibody Type Rabbit mAb Application WB, IHC P, ICC, ICFCM Reactivity Hu Purification Protein A Concentration 0. 25 mg ml Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0. 03% Proclin 300 Stability & Storage 12 months
Product Specification
| Host | Rabbit |
| Antigen | ERG |
| Synonyms | Transcriptional regulator ERG, Transforming protein ERG |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Nucleus |
| Accession | P11308 |
| Clone Number | SDT-190-65 |
| Antibody Type | Rabbit mAb |
| Application | WB, IHC-P, ICC, ICFCM |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 0.25 mg/ml |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| IHC-P | 1:1000 | |
| WB | 1:500 | |
| ICFCM | 1:250 | |
| ICC | 1:250 |
Background
ERG is an ETS family transcription factor (TF) frequently involved in human cancers, including leukemia [PMID: 21664289], prostate cancer [PMID: 16254181] and Ewing’s sarcoma [PMID: 8223458, PMID: 10561219]. It functions as an oncogene through chromosomal translocations or overexpression. In human leukemia, ERG was initially thought to play a role in leukemogenesis based on the t(16;21) translocation in acute myeloid leukemia (AML), leading to formation of the FUS (TLS)-ERG fusion [PMID: 8234289]. In some cases of AML with this translocation, the leukemia exhibits features of acute megakaryoblastic leukemia [PMID: 12091356].
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