SKU: 86468031419

HDAC1 Recombinant Rabbit mAb (HRP Conjugate) (SDT-310-72)

Sale price$108.00 Regular price$120.00
Save 10%

Pay in installments of $30.00 with ShopPay, AfterPay and Klarna

Shipping Estimate
USA
  • USA
  • CAN

Ships within 48 hours · Estimated delivery Aug 17 - Aug 22

Promo Codes Available:

For Your Every Summer RSVP, with Code: SUMMER15

Description

HDAC1 Recombinant Rabbit mAb (HRP Conjugate) (SDT-310-72)Product Specification Host Rabbit Antigen HDAC1 Synonyms Histone deacetylase 1; HD1; Protein deacetylase HDAC1 Immunogen Synthetic Peptide Location Nucleus Accession Q13547 Clone Number SDT 310 72 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu, Ms, Rt Positive Sample HeLa, Jurkat, K562, NIH 3T3, C6 Predicted Reactivity Bv Purification Protein A Concentration 1 mg ml Conjugation HRP Physical Appearance Liquid Storage Buffer PBS,

Product Specification


Host Rabbit
Antigen HDAC1
Synonyms Histone deacetylase 1; HD1; Protein deacetylase HDAC1
Immunogen Synthetic Peptide
Location Nucleus
Accession Q13547
Clone Number SDT-310-72
Antibody Type Recombinant mAb
Isotype IgG
Application WB
Reactivity Hu, Ms, Rt
Positive Sample HeLa, Jurkat, K562, NIH/3T3, C6
Predicted Reactivity Bv
Purification Protein A
Concentration 1 mg/ml
Conjugation HRP
Physical Appearance Liquid
Storage Buffer

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300

Stability & Storage 12 months from date of receipt / reconstitution, -20 °C as supplied.

Dilution


application dilution species
WB 1:10000 Hu, Ms, Rt

Background

Histone deacetylase 1 (HDAC1) is a key enzyme involved in the regulation of gene expression through the deacetylation of histone and non-histone proteins. As a zinc-dependent deacetylase, HDAC1 removes acetyl groups from lysine residues on histones, thereby tightening chromatin structure and inhibiting gene transcription. It is a component of several multiprotein complexes, such as the NuRD complex, which are involved in chromatin remodeling and transcriptional repression. HDAC1 plays a crucial role in various cellular processes, including cell cycle progression, differentiation, and development. In cancer, HDAC1 is often overexpressed and contributes to tumor progression by promoting cell proliferation and survival. For example, in colorectal cancer, HDAC1 enhances cell survival and proliferation in an ATG16L-dependent manner. Additionally, HDAC1 overexpression in cancer cells can be regulated by transcription factors like Sp1 and Sp3, which bind to the HDAC1 promoter and recruit other epigenetic modulators. In neurodegenerative diseases such as Alzheimer's disease, HDAC1 has been implicated in the regulation of oxidative DNA damage repair and synaptic function. Studies have shown that HDAC1 activity may be involved in the pathogenesis of Alzheimer's disease through its effects on DNA repair mechanisms and gene expression. HDAC1 is also a potential therapeutic target for neurological disorders, as HDAC inhibitors have shown promise in preclinical studies for treating conditions like Huntington's disease and Parkinson's disease.

Shipping Notes
  • Free Standard Shipping on $100+ Orders to the USA.
  • Except Preorder products are shipped in 48 hours.
  • Delivery to the USA:
  1. Standard Shipping : 3-10 business days
  • If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
  • We offer a 30-day return/exchange service after receiving.
  • Final sale items are not eligible for returns or exchanges.
  • To process your return/exchange, please contact us at [email protected]
  • Please click here for more details>>> Return & Exchange Policy
SKU: 86468031419

Discover Niche Categories That Outsell

Top-Converting Item to Boost Your Average Order

4.6 ★★★★★
Based on 8 reviews
Sort
Highest Rating
Newest First
Oldest First
Product Reviews
M
Verified Purchase
Marla
Bozeman, US
★★★★★ 5
UGG Comfort Without the Premium Price
Size: 9, Color: Beige, Size: 9, Color: Beige
These sandals are super cute and incredibly comfortable. They have that classic UGG look and feel, but at a much more approachable price point. The footbed is cushioned and supportive, making them easy to wear for extended periods. The straps feel secure without rubbing, and the overall construction feels solid and well made. They’re lightweight but still have a sturdy sole with good traction. They pair effortlessly with casual outfits and have that relaxed, elevated vibe UGG is known for—just without the higher price tag. A great value for both style and comfort.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on February 20, 2026
D
Verified Purchase
Diane
Omaha, US
★★★★★ 5
Ugg comfy shoes
Size: 7, Color: Black
So comfortable and cute as well. I wore these the first time and had to have everyone touch them to see how the sole would squish. Fit well, and are lightweight as well.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 26, 2026
T
Verified Purchase
Tracey PK
Charlottesville, US
★★★★★ 4
Comfy
Size: 7.5, Color: Green
Another review said they look like orthopedic shoes and I agree. But they are very comfortable
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 25, 2026
L
Verified Purchase
LovinShopping
Battle Creek, US
★★★★★ 5
Comfortable and cute
Size: 9, Color: Beige
Nice sandals
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 29, 2026
D
Verified Purchase
DENISE POWERS
Los Angeles, US
★★★★★ 5
Love them
Size: 11, Color: Brown
Runs a little large but great quality and feels great.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on March 28, 2026

recommand products