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Description
Human IGFBP-2 Protein, His TagProduct Specification Species Human Synonyms Insulin like growth factor binding protein 2, IBP 2, IGF binding protein 2, IGFBP 2, BP2, IBP2 Accession P18065 Amino Acid Sequence Protein sequence (P18065, Ala36 Gln325, with C His Tag)
Product Specification
| Species | Human |
| Synonyms | Insulin-like growth factor-binding protein 2, IBP-2, IGF-binding protein 2, IGFBP-2, BP2, IBP2 |
| Accession | P18065 |
| Amino Acid Sequence | Protein sequence (P18065, Ala36-Gln325, with C-His Tag) AEVLFRCPPCTPERLAACGPPPVAPPAAVAAVAGGARMPCAELVREPGCGCCSVCARLEGEACGVYTPRCGQGLRCYPHPGSELPLQALVMGEGTCEKRRDAEYGASPEQVADNGDDHSEGGLVENHVDSTMNMLGGGGSAGRKPLKSGMKELAVFREKVTEQHRQMGKGGKHHLGLEEPKKLRPPPARTPCQQELDQVLERISTMRLPDERGPLEHLYSLHIPNCDKHGLYNLKQCKMSLNGQRGECWCVNPNTGKLIQGAPTIRGDPECHLFYNEQQEARGVHTQRMQ |
| Expression System | HEK293 |
| Molecular Weight | Predicted MW: 33.1 kDa Observed MW: 33 kDa |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Conjugation | Unconjugated |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4 with 3% trehalose. |
| Reconstitution | Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation. |
| Stability & Storage | 12 months from date of receipt, -20 to -70 °C as supplied. |
Background
PVRIG (also known as CD112R) is an immune checkpoint protein belonging to the DNAM-1/TIGIT/CD96 family. It interacts with its ligand, PVRL2 (CD112), which is expressed on antigen-presenting cells and tumor cells. PVRIG functions as a co-inhibitory receptor, primarily expressed on T cells and NK cells, and plays a critical role in modulating immune responses. By binding to PVRL2, PVRIG suppresses T-cell and NK-cell activation, contributing to immune evasion in cancers.
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