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Description
Osteocalcin Recombinant Rabbit mAb ,PBS Only (SDT-2311-37)Product Specification Host Rabbit Antigen Osteocalcin Synonyms Bone Gla protein (BGP); Gamma carboxyglutamic acid containing protein; BGLAP Immunogen Synthetic Peptide Location Secreted Accession P02818 Clone Number SDT 2311 37 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Hu, Ms, Rt Purification Protein A Concentration 1 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS Stability & Storage
Product Specification
| Host | Rabbit |
| Antigen | Osteocalcin |
| Synonyms | Bone Gla protein (BGP); Gamma-carboxyglutamic acid-containing protein; BGLAP |
| Immunogen | Synthetic Peptide |
| Location | Secreted |
| Accession | P02818 |
| Clone Number | SDT-2311-37 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu, Ms, Rt |
| Purification | Protein A |
| Concentration | 1 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS |
| Stability & Storage | 12 months from date of receipt / reconstitution, 4 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:5000 | Hu |
| IHC-P | 1:2000 | Hu |
| ICC | 1:250 | Hu |
Background
Osteocalcin is a 49-residue, vitamin-K-dependent, γ-carboxyglutamic acid-rich protein synthesized exclusively by osteoblasts and odontoblasts that, once γ-carboxylated and incorporated into bone extracellular matrix where it regulates mineral maturation, can re-enter the circulation in an undercarboxylated form to act as a hormone that binds the GPCR6A receptor on pancreatic β-cells, adipocytes and myofibers to augment insulin secretion, enhance adiponectin expression and fuel muscle glucose uptake, thereby coupling skeletal remodeling to systemic energy metabolism and explaining why bone is an endocrine organ.
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