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Description
CX3CL1 Protein, MouseProduct Specification Species Mouse Synonyms Fractalkine,CX3CL1,C X3 C motif chemokine 1, CX3C membrane anchored chemokine, Neurotactin, Small inducible cytokine D1 Accession O35188 Amino Acid Sequence Gln25G Gly100 Expression System E. coli Molecular Weight 9kDa (Reducing) Purity >97% by SDS PAGE & HPLC Endotoxin <0. 1EU g Conjugation Unconjugated Tag No Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4 Reconstitution Reconstitute
Product Specification
| Species | Mouse |
| Synonyms | Fractalkine,CX3CL1,C-X3-C motif chemokine 1, CX3C membrane-anchored chemokine, Neurotactin, Small-inducible cytokine D1 |
| Accession | O35188 |
| Amino Acid Sequence | Gln25G-Gly100 |
| Expression System | E.coli |
| Molecular Weight | 9kDa (Reducing) |
| Purity | >97% by SDS-PAGE & HPLC |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference |
1. Front Immunol. 2021 Jun 7:12:664202. eCollection 2021. 2. Int J Mol Sci. 2023 Apr 27;24(9):7924. |
Background
Fractalkine or Chemokine (C-X3-C motif) ligand 1 belongs to the CX3C subgroup of chemokines, characterized by the number of amino acids located between the conserved cysteine residues. CX3CL1 exists in two forms: a membrane-bound form expressed by both endometrium cells and trophoblasts thought to be implicated in maternal-fetal interaction and a soluble form expressed by endometrium cells. This is the only member of the CX3C subgroup, which contains three amino acids between cysteine residues, resulting in a Cys-X-X-X-Cys configuration. Since the discovery of CX3CL1 and its receptor, CX3CR1 over twenty years ago, a wealth of evidence has emerged linking CX3CL1-CX3CR1 signalling to renal pathologies in both acute and chronic kidney diseases (CKD). CX3CL1 mitigates the negative effect of iron deficiency on the receptivity-related genes and proteins of HEC-1A endometrium cells, suggesting its important role in the regulation of endometrium receptivity.
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