SKU: 88791772366

p38 delta/MAPK13 + p38 alpha/MAPK14 Recombinant Mouse mAb (S-3860)

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Description

p38 delta/MAPK13 + p38 alpha/MAPK14 Recombinant Mouse mAb (S-3860)Product Specification Host Mouse Antigen p38 delta MAPK13 + p38 alpha MAPK14 Synonyms Mitogen activated protein kinase; MAP kinase; MAPK Location Cytoplasm, Nucleus Accession Q16539O15264 Clone Number S 3860 Antibody Type Mouse mAb Isotype IgG1,k Application WB, IHC P Reactivity Hu, Ms, Rt Positive Sample HeLa, Jurkat, A431, NIH 3T3 Predicted Reactivity BV, Dg, Hm, AfGrMk Purification Protein G Concentration 2 mg ml Conjugation Unconjugated Physical

Product Specification


Host Mouse
Antigen p38 delta/MAPK13 + p38 alpha/MAPK14
Synonyms Mitogen-activated protein kinase; MAP kinase; MAPK
Location Cytoplasm, Nucleus
Accession Q16539、O15264
Clone Number S-3860
Antibody Type Mouse mAb
Isotype IgG1,k
Application WB, IHC-P
Reactivity Hu, Ms, Rt
Positive Sample HeLa, Jurkat, A431, NIH/3T3
Predicted Reactivity BV, Dg, Hm, AfGrMk
Purification Protein G
Concentration 2 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300

Stability & Storage

12 months from date of receipt / reconstitution, -20 °C as supplied

Dilution


application dilution species
WB 1:1000 Hu, Ms
IHC-P 1:1000 Hu, Ms, Rt

Background

MAPK13 and MAPK14, commonly known as p38δ and p38α respectively, are critical members of the p38 mitogen-activated protein kinase (MAPK) signaling pathway. Functioning as essential intracellular signaling molecules, they are primarily activated in response to diverse stress stimuli, such as inflammatory cytokines, environmental stress, and oxidative stress. Their activation depends on the dual phosphorylation of specific threonine and tyrosine residues, which in turn regulates the activity of numerous downstream transcription factors and proteins. MAPK14 (p38α) is the most extensively studied and ubiquitously expressed isoform, playing a central role in processes like inflammatory responses, apoptosis, cell differentiation, and cell cycle regulation, making it a significant drug target for inflammatory and autoimmune diseases. In contrast, MAPK13 (p38δ) exhibits a more tissue-specific expression pattern, predominantly found in glandular tissues (e.g., salivary glands, pancreas), skin, and lungs, where it fulfills distinct roles in tissue-specific inflammation, skin pathophysiology, and the regulation of insulin secretion. Although they share upstream activators and some downstream substrates, MAPK13 and MAPK14 exhibit both overlapping and complementary physiological functions, collectively forming a core network for the precise cellular regulation of stress responses.

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SKU: 88791772366

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4.2 ★★★★★
Based on 27 reviews
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Otis H.
San Leandro, US
★★★★★ 4
Very nice shirt -Good Quality
Size: XX-Large, Color: Red (Retro Rose)
My husband is 6'1, weighs 178 pounds and normally wears a medium or large. Just for reference his pant size is a 32-34 depending on the brand. We ordered a large due to the fact the shirt appeared to be fitted more at the waist and from looking at the description I knew it would not have much stretch due to the satin type material. I was right. The large fit perfect and hung well. My husband use to be very large in shoulders and arms, but with age he has lost muscle mass, and recently lost a lot in his belly, so usually mediums fit perfect now. But when he put his large on, a medium would not have fit good to be comfortable & give proper fit in stomach area, so glad we went with the large. The shirt was purchased to go on a Virgin Cruise for Scarlett night, and he plans to wear black pants with it as in the picture the company posted, and this shirt will be perfect for that. It is a nice shirt, good quality, and if someone wanted it for an event/cruise or just for a night to dress up, especially for a Caribbean/Spanish or Latin dance theme, this shirt is a perfect look to me. Buy it, you will not be disappointed. He has not worn it yet, not washed it, but I would not put in it with other colors, may fade a little like reds do, and definitely, only dry on low/delicate. May need a pressing/steaming, but overall, it was not horribly wrinkled when we received it. A toss in the dryer may just do the trick. Was delivered on time as it said it would. Hope this info helps you.
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Reviewed in the United States on January 14, 2024
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Avery Hughes
Alexandria, US
★★★★★ 5
Yeehaw!
I like this shirt. Very fancy yet western.
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Reviewed in the United States on January 20, 2026
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Amazon Customer
Natrona Heights, US
★★★★★ 5
Great quality shirt, comfy, and loved the embroidery!
Size: X-Large, Color: Pure Black (Retro Rose), Size: X-Large, Color: Pure Black (Retro Rose)
Great quality shirt, especially for the price. The embroidery is fantastic. Ordered for a costume party, but is a great shirt for wearing out anytime.
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Reviewed in the United States on January 29, 2026
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Ron
Charlottesville, US
★★★★★ 3
Professionally clean or iron
Size: Medium, Color: Red (Retro Rose)
Looks good and at 5'7" and 145 lbs a medium fit me great. Plan on either professional cleaning or some time at the ironing board to make it look its best. The
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Reviewed in the United States on December 11, 2025
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John Speedy
Draper, US
★★★★★ 5
Quality is great
Size: XX-Large, Color: Black (Retro Rose)
Love it it looks and feels great
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Reviewed in the United States on June 5, 2026

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