SKU: 89508503132

NFIB / NF1B2 Recombinant Rabbit mAb (S-3046-78)

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Description

NFIB / NF1B2 Recombinant Rabbit mAb (S-3046-78)Product Specification Host Rabbit Antigen NFIB NF1B2 Synonyms Nuclear factor 1 B type; NF1 B; Nuclear factor 1 B; CCAAT box binding transcription factor (CTF); Nuclear factor I B (NF I B; NFI B); TGGCA binding protein Immunogen Synthetic Peptide Location Nucleus Accession O00712 Clone Number S 3046 78 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu, Ms, Rt Positive Sample RPMI 8226, MCF7, HeLa, NIH 3T3 Predicted Reactivity Bv,

Product Specification


Host Rabbit
Antigen NFIB / NF1B2
Synonyms Nuclear factor 1 B-type; NF1-B; Nuclear factor 1/B; CCAAT-box-binding transcription factor (CTF); Nuclear factor I/B (NF-I/B; NFI-B); TGGCA-binding protein
Immunogen Synthetic Peptide
Location Nucleus
Accession O00712
Clone Number S-3046-78
Antibody Type Recombinant mAb
Isotype IgG
Application WB
Reactivity Hu, Ms, Rt
Positive Sample RPMI-8226, MCF7, HeLa, NIH/3T3
Predicted Reactivity Bv, Hm
Purification Protein A
Concentration 0.5 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300

Stability & Storage

12 months from date of receipt / reconstitution, -20 °C as supplied

Dilution


application dilution species
WB 1:1000 Hu, Ms, Rt

Background

The NFIB protein, also known as Nuclear Factor I B or NF1B2, is a transcription factor belonging to the NFI (Nuclear Factor I) family of site-specific DNA-binding proteins that play crucial roles in regulating gene expression during development and cellular differentiation. Encoded by the NFIB gene located on human chromosome 9p23-p22, this protein contains a highly conserved N-terminal DNA-binding domain that recognizes the palindromic consensus sequence 5'-TTGGC(N)5GCCAA-3', thereby controlling the transcription of target genes involved in various biological processes including brain development, lung maturation, and skeletal patterning. NFIB functions as both a transcriptional activator and repressor depending on cellular context and promoter architecture, and it forms homodimers or heterodimers with other NFI family members (NFIA, NFIC, and NFID) to exert its regulatory effects. During embryonic development, NFIB is essential for proper formation of the corpus callosum, cerebellar vermis, and facial structures, while in the postnatal period it regulates terminal differentiation of various cell types including chondrocytes, osteoblasts, and respiratory epithelial cells. Aberrant NFIB expression or function has been implicated in multiple pathological conditions, including certain forms of intellectual disability, craniofacial abnormalities, and various cancers where it can act as either an oncogene or tumor suppressor depending on the tissue type. The protein's activity is modulated through post-translational modifications and interactions with various co-activators and co-repressors, making it a critical node in the gene regulatory networks that govern mammalian development and homeostasis.

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SKU: 89508503132

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4.6 ★★★★★
Based on 7 reviews
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A
Verified Purchase
Amber L.
Draper, US
★★★★★ 5
Actually indestructible!
Style: Two pack
I am always leery of items marked indestructible because my 100+ lb. dog chews through anything I buy him. But not this. It's solid plastic that he LOVES to chew on. And I love that there are 2 of them so he can have them in alternative places to play with. The shape and texture seems to entice him and keep him occupied for a few minutes, which is a blessing!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 16, 2026
B
Verified Purchase
Barbara Ellen Large
Bozeman, US
★★★★★ 5
Great product.He's still chewing on them.That's what I want
Style: Two pack
Bought forever ago and he's still chewing on them.Great product strong dog
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Reviewed in the United States on May 3, 2026
C
Verified Purchase
Crickett
Cuba, US
★★★★★ 4
Indestructible
Style: Two pack
Hard on wood floors but lasts forever. Helps keep teeth clean too.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on March 20, 2026
G
Verified Purchase
Gail storer
Chelsea, US
★★★★★ 5
Control dogs aggressive chewing habit.
Style: Two pack
My dog loves them she is an aggressive chewers they relieve her boredom and keep her teeth tartar free. I had to throw her first bone shaped toy she whittled it down so much.she didn't like the ring shaped I got her likes the bone shape better d finitely would recommend them.
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Reviewed in the United States on March 4, 2026
J
Verified Purchase
Jess💁🏼‍♀️✨
Pawtucket, US
★★★★★ 1
EDIT: *NOT* great for aggressive chewers!!! ☹️
Style: Two pack, Style: Two pack
UPDATE (previous 5⭐️): Yep. Things changed!! I take it alllll back!😩🤦🏼‍♀️ Here we are, just shy of a month and they’re both toast!!! The pics might not look like a big deal, but we tossed the orange one after finding the chewed off bits in his poop. The only reason I was able to take a pic of this blue one is because we couldn’t find it until now. However, the orange one looked the same when we tossed it, so I’m sure we’ll be finding blue bits in his poop. Not a fan of ANY chew toy he can actually end up eating!! I have PTSD from our last fur baby that suddenly decided he liked to swallow socks @ 11yo & ended up needing emergency surgery to the tune of ~$5K!🥴 These are crazy!! They’re super hard plastic, almost like glass. I wasn’t expecting that! My hubs was joking they’re for seggy time, not dogs! 🫣😂 We got a puppy in April that is an aggressive chewer. We’ve both had dogs most of our lives, but this aggressive chewing is new to both of us. Lil dude has chewed through a ton of other toys advertised for aggressive chewers- a few within just hours!! It’s wild!! We’re not used to it, but he loves his toys, so we keep trying to get him ones that will last! 😅 We only got this 2-pk yesterday morning, but he’s been obsessed & so far, so good! With how hard they are, I’m feeling very confident they’ll last longer than any other toy we’ve bought him!! I will update if anything changes!
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Reviewed in the United States on August 25, 2025

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