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Description
NF-κB2 p100/p52 Recombinant Rabbit mAb (S-2502-70)Product Specification Host Rabbit Antigen NF B2 p100 p52 Synonyms Nuclear factor NF kappa B p100 subunit; DNA binding factor KBF2; H2TF1; Lymphocyte translocation chromosome 10 protein; Nuclear factor of kappa light polypeptide gene enhancer in B cells 2; Oncogene Lyt 10 (Lyt10); LYT10; NFKB2 Immunogen Recombinant Protein Location Cytoplasm, Nucleus Accession Q00653 Clone Number S 2502 70 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC
Product Specification
| Host | Rabbit |
| Antigen | NF-κB2 p100/p52 |
| Synonyms | Nuclear factor NF-kappa-B p100 subunit; DNA-binding factor KBF2; H2TF1; Lymphocyte translocation chromosome 10 protein; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2; Oncogene Lyt-10 (Lyt10); LYT10; NFKB2 |
| Immunogen | Recombinant Protein |
| Location | Cytoplasm, Nucleus |
| Accession | Q00653 |
| Clone Number | S-2502-70 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu, Mk |
| Positive Sample | HeLa, HDLM-2, Karpas-299, MCF7, THP-1, COS-7 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Mk |
| IHC-P | 1:50 | Hu |
| ICC | 1:100 | Hu |
Background
NF-κB2 p100 is a 100 kDa cytoplasmic precursor protein encoded by the nfkb2 gene that functions both as an IκB-like inhibitor of NF-κB—sequestering RelB and other subunits in the cytoplasm—and as the obligate source of the mature NF-κB2 p52 subunit generated via stimulus-induced, phosphorylation- and ubiquitin-dependent partial proteasomal processing triggered by the alternative NF-κB pathway kinases NIK and IKKα, thereby enabling p52-RelB dimers to translocate to the nucleus and drive transcriptional programs essential for lymphoid organogenesis, B-cell maturation and adaptive immunity.
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