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Description
Lamin B1 Recombinant Rabbit mAb (SDT-307-108)Product Specification Host Rabbit Antigen Lamin B1 Synonyms LMNB1; Lamin B1 Location Nucleus lamina Accession P20700 Clone Number SDT 307 108 Antibody Type Recombinant mAb Application WB, IHC P, IP, IF, ChIP Reactivity Hu, Ms, Rt Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0. 03% Proclin 300 Stability & Storage 12 months from date of receipt
Product Specification
| Host | Rabbit |
| Antigen | Lamin B1 |
| Synonyms | LMNB1; Lamin-B1 |
| Location | Nucleus lamina |
| Accession | P20700 |
| Clone Number | SDT-307-108 |
| Antibody Type | Recombinant mAb |
| Application | WB, IHC-P, IP, IF, ChIP |
| Reactivity | Hu, Ms, Rt |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:5000-1:50000 | |
| IP | 1:50 | |
| IHC | 1:2000 | |
| IF | 1:500 | |
| ChIP | 1:20-1:50 |
Background
Lamin-B1 is a protein that in humans is encoded by the LMNB1 gene. It is one of the essential members of the nuclear lamina protein family. Its main function is to maintain the integrity of nuclear skeleton, as well as to participate in the cell proliferation and aging by affecting the chromosome distribution. gene expression, and DNA damage repair. The abnormal expression of lamin B1 is related to certain diseases, including neurological diseases [e.g. neural tube defects (NDTs), adult-onset autosomal dominant leukodystrophy (ADLD)] and tumors (e.g. pancreatic cancer). It is also a potential tumor marker as well as drug target [PMID: 30499270].
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