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Description
Alexa Fluor® 647 Mouse Anti-Human CD123 Antibody (S-R442)Product Specification Host Mouse Antigen CD123 Synonyms Interleukin 3 receptor subunit alpha; IL 3 receptor subunit alpha; IL 3R subunit alpha; IL 3R alpha; IL 3RA; IL3RA; IL3R Location Cell membrane Accession P26951 Clone Number S R442 Antibody Type Mouse mAb Isotype IgG2a,k Application FCM Reactivity Hu Positive Sample human PBMC Purification Protein A Concentration 0. 2 mg ml Conjugation Alexa Fluor 647 Physical Appearance Liquid Storage Buffer
Product Specification
| Host | Mouse |
| Antigen | CD123 |
| Synonyms | Interleukin-3 receptor subunit alpha; IL-3 receptor subunit alpha; IL-3R subunit alpha; IL-3R-alpha; IL-3RA; IL3RA; IL3R |
| Location | Cell membrane |
| Accession | P26951 |
| Clone Number | S-R442 |
| Antibody Type | Mouse mAb |
| Isotype | IgG2a,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | human PBMC |
| Purification | Protein A |
| Concentration | 0.2 mg/ml |
| Conjugation | Alexa Fluor® 647 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 25% Glycerol, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Hu |
Background
CD123, also known as the alpha chain of the interleukin-3 receptor (IL-3Rα), is a membrane-bound protein that plays a crucial role in immune regulation and hematopoiesis. It is overexpressed in various hematologic malignancies, including acute myeloid leukemia (AML), blastic plasmacytoid dendritic cell neoplasm (BPDCN), acute lymphoblastic leukemia (ALL), hairy cell leukemia, and systemic mastocytosis. The CD123 protein consists of three extracellular domains, a single-pass transmembrane domain, and a short intracellular region. It is involved in the growth, proliferation, survival, and differentiation of hematopoietic cells. CD123 is particularly significant as a biomarker for targeted therapy in these diseases, with various pharmacologic strategies and agents under investigation or already approved for clinical use. For instance, Tagraxofusp, an anti-CD123 antibody conjugated to diphtheria toxin, has been approved for use in patients with BPDCN.
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