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Description
Mouse Anti-Human TIM-3 Antibody (S-R642)Product Specification Host Mouse Antigen TIM 3 Synonyms Hepatitis A virus cellular receptor 2; HAVcr 2; T cell immunoglobulin and mucin domain containing protein 3 (TIMD 3); T cell immunoglobulin mucin receptor 3 (TIM 3); T cell membrane protein 3; CD366; TIM3; TIMD3; HAVCR2 Location Cell membrane, Cell junction Accession Q8TDQ0 Clone Number S R642 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Hu Positive Sample Human PBMC
Product Specification
| Host | Mouse |
| Antigen | TIM-3 |
| Synonyms | Hepatitis A virus cellular receptor 2; HAVcr-2; T-cell immunoglobulin and mucin domain-containing protein 3 (TIMD-3); T-cell immunoglobulin mucin receptor 3 (TIM-3); T-cell membrane protein 3; CD366; TIM3; TIMD3; HAVCR2 |
| Location | Cell membrane, Cell junction |
| Accession | Q8TDQ0 |
| Clone Number | S-R642 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | Human PBMC |
| Purification | Protein G |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 1:2000 | Hu |
Background
TIM-3 (T-cell immunoglobulin and mucin-domain containing-3) is a transmembrane checkpoint receptor selectively expressed on interferon-γ-producing T cells, Tregs, and innate immune cells; engagement of its ligands (galectin-9, CEACAM1, HMGB1, phosphatidylserine) triggers inhibitory signaling that terminates Th1 responses, promotes T-cell exhaustion, and fosters tolerogenic dendritic cell activity, thereby serving as a key negative regulator of antitumor and antimicrobial immunity and representing an actionable target for cancer immunotherapy.
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Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
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