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Description
G3BP1 Rabbit Polyclonal AntibodyProduct Specification Host Rabbit Antigen G3BP1 Synonyms Ras GTPase activating protein binding protein 1; G3BP 1; ATP dependent DNA helicase VIII (hDH VIII); GAP SH3 domain binding protein 1; G3BP Immunogen Synthetic Peptide Location Cytoplasm, Nucleus Accession Q13283 Antibody Type Polyclonal antibody Isotype IgG Application WB, IHC P, ICC Reactivity Hu, Ms, Rt Positive Sample HEK 293, Jurkat, HeLa, Neruo 2a, C6 Predicted Reactivity Or, Bv
Product Specification
| Host | Rabbit |
| Antigen | G3BP1 |
| Synonyms | Ras GTPase-activating protein-binding protein 1; G3BP-1; ATP-dependent DNA helicase VIII (hDH VIII); GAP SH3 domain-binding protein 1; G3BP |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Nucleus |
| Accession | Q13283 |
| Antibody Type | Polyclonal antibody |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | HEK-293, Jurkat, HeLa, Neruo-2a, C6 |
| Predicted Reactivity | Or, Bv |
| Purification | Immunogen Affinity |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt |
| IHC-P | 1:100 | Hu, Ms, Rt |
| ICC | 1:500 | Hu |
Background
G3BP1, also known as Ras-GTPase-activating protein-binding protein 1, is a multifunctional protein involved in various biological processes. It is best known for its role in stress granule (SG) formation, where it acts as a molecular switch to trigger liquid-liquid phase separation (LLPS) and assemble membraneless compartments that store mRNAs and proteins during cellular stress. G3BP1 also functions as an ATP- and magnesium-dependent helicase, unwinding DNA/DNA, RNA/DNA, and RNA/RNA substrates. Additionally, it plays a crucial role in innate immunity by promoting the activity of cGAS and RIG-I, which are key components of the DNA- and RNA-sensing pathways. In disease contexts, G3BP1 is implicated in cancer progression and neurodegenerative disorders, highlighting its significance in both normal and pathological cellular functions.
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