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Description
IL-12/IL-23 p40 Monomer Protein, RatProduct Specification Species Rat Synonyms Interleukin 12 subunit beta,IL 12B,Cytotoxic lymphocyte maturation factor 40 kDa subunit (CLMF p40),IL 12 subunit p40 Accession Q9R278 Amino Acid Sequence Met23 Ser335 Expression System HEK293 Molecular Weight 40 45 kDa (Reducing) Purity >95% by SDS PAGE and HPLC. Endotoxin <0. 1EU g Conjugation Unconjugated Tag No Tag Physical Appearance Lyophilized powder Storage Buffer PBS, pH7. 4 Reconstitution
Product Specification
| Species | Rat |
| Synonyms | Interleukin-12 subunit beta,IL-12B,Cytotoxic lymphocyte maturation factor 40 kDa subunit (CLMF p40),IL-12 subunit p40 |
| Accession | Q9R278 |
| Amino Acid Sequence | Met23-Ser335 |
| Expression System | HEK293 |
| Molecular Weight | 40-45 kDa (Reducing) |
| Purity | >95% by SDS-PAGE and HPLC. |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | ·12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | J Biol Chem. 2013 Mar 1;288(9):6763-76. |
Background
Interleukin-12 (IL-12) is a heterodimeric cytokine composed of two subunits, p35 and p40, which are linked by disulfide bonds. IL-12 plays a critical role in the regulation of immune responses, particularly in the differentiation of T helper 1 (Th1) cells and the activation of natural killer (NK) cells. The p40 subunit is shared between IL-12 and IL-23, another important cytokine involved in immune regulation. In rats, IL-12 p40 is primarily produced by antigen-presenting cells such as macrophages and dendritic cells. It is essential for the initiation and maintenance of Th1 responses, which are crucial for adaptive cellular immunity. Additionally, IL-12 p40 can exist as a homodimer or monomer, which can act as an antagonist to IL-12.
The p40 subunit is a target for therapeutic interventions in autoimmune and inflammatory diseases. Monoclonal antibodies against IL-12 p40 have been developed to inhibit its activity and reduce inflammation. Also, IL-12 has potent antitumor activity by stimulating the immune system to attack cancer cells. Recombinant IL-12 or IL-12 vectors are being explored as potential cancer treatments.
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