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Description
Cardiac troponin T (TNNT2) Recombinant Rabbit mAb ,PBS Only (SDT-2894-34)Product Specification Host Rabbit Antigen Cardiac troponin T (TNNT2) Synonyms Troponin T, cardiac muscle; TnTc; Cardiac muscle troponin T (cTnT) Immunogen Recombinant Protein Accession P45379 Clone Number SDT 2894 34 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, IF Reactivity Hu, Ms, Rt Positive Sample Human heart, mouse heart, rat heart Purification Protein A Concentration 0. 25 mg ml Conjugation Unconjugated Physical Appearance
Product Specification
| Host | Rabbit |
| Antigen | Cardiac troponin T (TNNT2) |
| Synonyms | Troponin T, cardiac muscle; TnTc; Cardiac muscle troponin T (cTnT) |
| Immunogen | Recombinant Protein |
| Accession | P45379 |
| Clone Number | SDT-2894-34 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, IF |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | Human heart, mouse heart, rat heart |
| Purification | Protein A |
| Concentration | 0.25 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 4 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:2000 | Ms, Rt |
| IHC-P | 1:1000 | Hu, Ms, Rt |
| ICC | 1:250 | Hu |
Background
Cardiac troponin T (TNNT2) is a 35.9 kDa, 295-amino-acid striated-muscle-specific protein that forms the troponin T component of the troponin complex on the thin filament, where it tethers the troponin C–I sub-complex to tropomyosin; by transducing the Ca²⁺-induced conformational change of troponin C into tropomyosin movement, TNNT2 orchestrates the steric switch that exposes myosin-binding sites on actin and thus initiates systolic contraction, while its unique N-terminal peptide sequence allows ultra-sensitive immunoassay detection—making any elevation in blood TNNT2 the gold-standard biomarker for myocardial injury—yet mutations that enhance or suppress myofilament Ca²⁺ sensitivity, destabilize the N-tail, or promote aberrant splice variants are linked to hypertrophic, dilated, or restrictive cardiomyopathies, arrhythmogenic right ventricular cardiomyopathy, and sudden cardiac death, underscoring its dual role as both a molecular motor controller and a sentinel of cardiac integrity.
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